ArticlePesticide biochemistry and physiology2010
Regulation of cytochrome P450 expression in Drosophila: Genomic insights.
Article in Pesticide biochemistry and physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 86 citations in OpenAlex.
- Genome-wide identification of the cytochrome P450 superfamily in Trichoplusia ni and in-silico expression of resistance against HDAC inhibitors.Scientific reports · 2025Article
- IntegratingFrontiers in pharmacology · 2025Article
- CYP4BN4v7 regulates the population density dependent oocyte maturity rate in bean beetles.Scientific reports · 2024Article
- Unveiling candidate genes for metabolic resistance to malathion in Aedes albopictus through RNA sequencing-based transcriptome profiling.PLoS neglected tropical diseases · 2024Article
- Two oppositely-charged sf3b1 mutations cause defective development, impaired immune response, and aberrant selection of intronic branch sites in Drosophila.PLoS genetics · 2021Article
- Identification and characterization of CYPs induced in the Drosophila antenna by exposure to a plant odorant.Scientific reports · 2021Article
- RNA-Seq analysis of the blue light-emitting Orfelia fultoni (Diptera: Keroplatidae) suggest photoecological adaptations at the molecular level.Comparative biochemistry and physiology. Part D, Genomics & proteomics · 2021Article
- Genome-wide identification and gene-editing of pigment transporter genes in the swallowtail butterfly Papilio xuthus.BMC genomics · 2021Article
- Poly(ADP-ribose) polymerase 1 in genome-wide expression control in Drosophila.Scientific reports · 2020Article
- Alkaline Ceramidase Mediates the Oxidative Stress Response in Drosophila melanogaster Through Sphingosine.Journal of insect science (Online) · 2019Article
- The effect of insecticide synergist treatment on genome-wide gene expression in a polyphagous pest.Scientific reports · 2017Article
- Splice form variant and amino acid changes in MDR49 confers DDT resistance in transgenic Drosophila.Scientific reports · 2016Article
- Insecticide-mediated up-regulation of cytochrome P450 genes in the red flour beetle (Tribolium castaneum).International journal of molecular sciences · 2015Article
- Effect of Low Doses (5-40 cGy) of Gamma-irradiation on Lifespan and Stress-related Genes Expression Profile in Drosophila melanogaster.PloS one · 2015Article
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- Insecticidal activity and expression of cytochrome P450 family 4 genes in Aedes albopictus after exposure to pyrethroid mosquito coils.The protein journal · 2014Article
- Molecular cloning and xenobiotic induction of seven novel cytochrome P450 monooxygenases in Aedes albopictus.Journal of insect science (Online) · 2014Article
- Effects of caste on the expression of genes associated with septic injury and xenobiotic exposure in the Formosan subterranean termite.PloS one · 2014Article
- The mechanisms underlying α-amanitin resistance in Drosophila melanogaster: a microarray analysis.PloS one · 2014Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Genomic tools such as the availability of the Drosophila genome sequence, the relative ease of stable transformation, and DNA microarrays have made the fruit fly a powerful model in insecticide toxicology research. We have used transgenic promoter-GFP constructs to document the detailed pattern of induced Cyp6a2 gene expression in larval and adult Drosophila tissues. We also compared various insecticides and xenobiotics for their ability to induce this cytochrome P450 gene, and show that the pattern of Cyp6a2 inducibility is comparable to that of vertebrate CYP2B genes, and different from that of vertebrate CYP1A genes, suggesting a degree of evolutionary conservation for the "phenobarbital-type" induction mechanism. Our results are compared to the increasingly diverse reports on P450 induction that can be gleaned from whole genome or from "detox" microarray experiments in Drosophila. These suggest that only a third of the genomic repertoire of CYP genes is inducible by xenobiotics, and that there are distinct subsets of inducers / induced genes, suggesting multiple xenobiotic transduction mechanisms. A relationship between induction and resistance is not supported by expression data from the literature. The relative abundance of expression data now available is in contrast to the paucity of studies on functional expression of P450 enzymes, and this remains a challenge for our understanding of the toxicokinetic aspects of insecticide action.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.