SynthesisPLoS neglected tropical diseases2010
The global burden of alveolar echinococcosis.
Synthesis in PLoS neglected tropical diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 248 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
248 citing papers in PubMed, 7 syntheses or guidelines pooled it, 522 citations in OpenAlex.
- Alveolar Echinococcosis in the Early 2020s: A Systematic Review.Pathogens (Basel, Switzerland) · 2026Pooled it
- The prevalence of hydatid cyst in raw meat products: a global systematic review, meta-analysis, and meta-regression.Scientific reports · 2024Pooled it
- The dual burden of animal and human zoonoses: A systematic review.PLoS neglected tropical diseases · 2022Pooled it
- Prevalence of human alveolar echinococcosis in China: a systematic review and meta-analysis.BMC public health · 2020Pooled it
- Source attribution of human echinococcosis: A systematic review and meta-analysis.PLoS neglected tropical diseases · 2020Pooled it
- Worldwide literature on epidemiology of human alveolar echinococcosis: a systematic review of research published in the twenty-first century.Infection · 2019Pooled it
- Potential risk factors associated with human alveolar echinococcosis: Systematic review and meta-analysis.PLoS neglected tropical diseases · 2017Pooled it
- Correlation between imaging features and rEm18 antibodies in alveolar echinococcosis: results from a multicenter study in France.Parasite (Paris, France) · 2025Trial
- Presence of red foxes and contamination withFood and waterborne parasitology · 2026Article
- The medical and surgery outcomes of pulmonary hydatid cyst disease: A 12-year multidisciplinary experience.Irish journal of medical science · 2026Article
- Postoperative CT-derived spleen volumetry for recurrence risk stratification after curative-intent surgery for hepatic alveolar echinococcosis.Infection · 2026Article
- A cost-outcome assessment of dog deworming for echinococcosis control in the Xizang Autonomous Region, China, 2016-2022.PLoS neglected tropical diseases · 2026Article
- Effects of Exosomes Derived from Hydatid Cyst Stem Cells on Human Hepatocytes.Acta parasitologica · 2026Article
- Annual assessment ofEFSA journal. European Food Safety Authority · 2026Article
- Optimization of regional echinococcosis control strategies in Xizang: a health economics perspective.Tropical medicine and health · 2026Article
- A Rare Case of Hepatic Echinococcus granulosus Infection Diagnosed by Autopsy in Japan.Internal medicine (Tokyo, Japan) · 2026Article
- Therapeutic effects of IL-33/ST-2 pathway inhibition combined with albendazole on hepatic fibrosis and immune regulation in alveolar echinococcosis: in vivo and in vitro evidence.Parasites & vectors · 2026Article
- Assessment of environmental contamination with Echinococcus spp. through DNA detection in free-roaming canid feces and soil in human echinococcosis hotspots from the Three-River-Source Region of the Qinghai-Tibet Plateau, China.Parasites & vectors · 2026Article
- Seroprevalence and Risk Factors of Cystic Echinococcosis in Cattle and Buffaloes: Insights From an In-House ELISA.Veterinary medicine and science · 2026Article
- Diagnosis of hepatic alveolar echinococcosis:18F-FDG-PET activity compared to the Echinococcus multilocularis Ulm Ultrasound Classification.Nuklearmedizin. Nuclear medicine · 2026Article
188 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHuman alveolar echinococcosis (AE) is known to be common in certain rural communities in China whilst it is generally rare and sporadic elsewhere. The objective of this study was to provide a first estimate of the global incidence of this disease by country. The second objective was to estimate the global disease burden using age and gender stratified incidences and estimated life expectancy with the disease from previous results of survival analysis. Disability weights were suggested from previous burden studies on echinococcosis. METHODOLOGY/PRINCIPAL
findingsWe undertook a detailed review of published literature and data from other sources. We were unable to make a standardised systematic review as the quality of the data was highly variable from different countries and hence if we had used uniform inclusion criteria many endemic areas lacking data would not have been included. Therefore we used evidence based stochastic techniques to model uncertainty and other modelling and estimating techniques, particularly in regions where data quality was poor. We were able to make an estimate of the annual global incidence of disease and annual disease burden using standard techniques for calculation of DALYs. Our studies suggest that there are approximately 18,235 (CIs 11,900-28,200) new cases of AE per annum globally with 16,629 (91%) occurring in China and 1,606 outside China. Most of these cases are in regions where there is little treatment available and therefore will be fatal cases. Based on using disability weights for hepatic carcinoma and estimated age and gender specific incidence we were able to calculate that AE results in a median of 666,434 DALYs per annum (CIs 331,000-1.3 million). CONCLUSIONS/SIGNIFICANCE: The global burden of AE is comparable to several diseases in the neglected tropical disease cluster and is likely to be one of the most important diseases in certain communities in rural China on the Tibetan plateau.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.