Evidence map›Paper›PMID 20582290›Full record

ArticleFrontiers in neuroscience2009

Neurobiology of inflammation-associated anorexia.

Laurent Gautron, Sophie Layé

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
1.0field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 69 citations in OpenAlex.

  1. Review
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  10. Editorial: Physiology and pathology of neuroglia.Frontiers in cellular neuroscience · 2023
    Article
  11. Review
  12. LPS induces rapid increase in GDF15 levels in mice, rats, and humans but is not required for anorexia in mice.American journal of physiology. Gastrointestinal and liver physiology · 2022
    Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Gastrointestinal and hepatic manifestations of COVID-19: A systematic review and meta-analysis.JGH open : an open access journal of gastroenterology and hepatology · 2021
    Article
  19. Metabolomics as a Tool to Investigate HIV/TB Co-Infection.Frontiers in molecular biosciences · 2021
    Review
  20. Malnutrition in cirrhosis: More food for thought.World journal of hepatology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Laurent GautronThe University of Texas Southwestern Medical Center Dallas, TX, USA.
Sophie Layé
The University of Texas Southwestern Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Compelling data demonstrate that inflammation-associated anorexia directly results from the action of pro-inflammatory factors, primarily cytokines and prostaglandins E2, on the nervous system. For instance, the aforementioned pro-inflammatory factors can stimulate the activity of peripheral sensory neurons, and induce their own de novo synthesis and release into the brain parenchyma and cerebrospinal fluid. Ultimately, it results in the mobilization of a specific neural circuit that shuts down appetite. The present article describes the different cell groups and neurotransmitters involved in inflammation-associated anorexia and examines how they interact with neural systems regulating feeding such as the melanocortin system. A better understanding of the neurobiological mechanisms underlying inflammation-associated anorexia will help to develop appetite stimulants for cancer and AIDS patients.

Indexed as

appetitebraincachexiainflammationinterleukin-1melanocortin

Identifiers

PMID20582290
PMCPMC2858622
OpenAlexW2056932790

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.