Evidence map›Paper›PMID 20582282›Full record

ArticleFrontiers in neuroscience2009

Genetics of the hippocampal transcriptome in mouse: a systematic survey and online neurogenomics resource.

Rupert W Overall, Gerd Kempermann, Jeremy Peirce, Lu Lu, Dan Goldowitz, Fred H Gage, Shirlean Goodwin, August B Smit, David C Airey, Glenn D Rosen and 5 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 73 citations in OpenAlex.

  1. Article
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  6. Highlights from the Era of Open Source Web-Based Tools.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
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  8. Identifying modifier genes for hypertrophic cardiomyopathy.Journal of molecular and cellular cardiology · 2020
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  12. Review
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  14. Article
  15. Ethanol's Effect onFrontiers in genetics · 2018
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Rupert W OverallGenomics of Regeneration, DFG Research Center for Regenerative Therapies Dresden, Technische Universität Dresden, Germany.
Gerd Kempermann
Jeremy Peirce
Lu Lu
Dan Goldowitz
Fred H Gage
Shirlean Goodwin
August B Smit
David C Airey
Glenn D Rosen
Leonard C Schalkwyk
Thomas R Sutter
Richard S Nowakowski
Stephen Whatley
Robert W Williams
TU Dresden · DE

Funding

MOUSE BIRNU24RR021760 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TOGA, ARTHUR W · 2005 to 2009
$11.6M
Modeling heterogeneity for safe cancer prevention and detectionU01CA105417 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI THREADGILL, DAVID W. · 2004 to 2013
$6.7M
INFORMATICS CENTER FOR MOUSE NEUROGENETICSP20MH062009 · NIMH · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI WILLIAMS, ROBERT W. W · 2000 to 2004
$5.9M
Informatics Center for Mouse NeurogeneticsP20DA021131 · NIDA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI WILLIAMS, ROBERT W. · 2005 to 2009
$5.0M
Systems Genetics of Alcohol Response and Stress Effects in CNSU01AA013499 · NIAAA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI WILLIAMS, ROBERT W. · 2002 to 2016
$4.8M
INIA: Consortium-Bioanalytical CoreU01AA013515 · NIAAA · UNIVERSITY OF MEMPHIS · PI SUTTER, THOMAS R · 2002 to 2006
$2.4M
INIA: Genetic Analysis of Alcohol Consumption and StressU01AA013503 · NIAAA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI GOLDOWITZ, DANIEL · 2002 to 2006
$2.3M
Genetic Analysis of Ethanol-Mediated Stress ReductionU01AA014425 · NIAAA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI LU, LU · 2004 to 2008
$2.1M
QTL mapping of cell number in the mouse CNSR01NS052397 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ROSEN, GLENN D · 2007 to 2011
$1.8M
Phenomic analysis of the murine hippocampusR01NS049445 · NINDS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI NOWAKOWSKI, RICHARD S · 2004 to 2007
$1.4M
INIA: Genotyping CoreU01AA013513 · NIAAA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI WILLLIAMS, ROBERT W · 2002 to 2006
$753k
NCI NIH HHS U01 CA105417NCRR NIH HHS U24 RR021760NIAAA NIH HHS U01 AA013499NIAAA NIH HHS U01 AA013503NIAAA NIH HHS U01 AA013513NIAAA NIH HHS U01 AA013515NIAAA NIH HHS U01 AA014425NIDA NIH HHS P20 DA021131NIMH NIH HHS P20 MH062009NINDS NIH HHS R01 NS049445NINDS NIH HHS R01 NS052397
6 · The paper itself

Abstract

Differences in gene expression in the CNS influence behavior and disease susceptibility. To systematically explore the role of normal variation in expression on hippocampal structure and function, we generated an online microarray database for a diverse panel of strains of mice, including most common inbred strains and numerous recombinant inbred lines (www.genenetwork.org). Using this resource, coexpression networks for families of genes can be generated rapidly to test causal models related to function. The data set is optimized for quantitative trait locus (QTL) mapping and was used to identify over 5500 QTLs that modulate mRNA levels. We describe a wide variety of analyses and novel synthetic approaches that take advantage of this resource, and demonstrate how both the data and associated tools can be applied to the study of gene regulation in the hippocampus and relations to structure and function.

Indexed as

genetical genomicshippocampusQTLrecombinant inbred micetranscript expression

Identifiers

PMID20582282
PMCPMC2858614
OpenAlexW2160017262

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.