ArticleNature neuroscience2010
A light-gated, potassium-selective glutamate receptor for the optical inhibition of neuronal firing.
Article in Nature neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 131 citations in OpenAlex.
- Kalium channelrhodopsins effectively inhibit neurons.Nature communications · 2024Article
- WiChR, a highly potassium-selective channelrhodopsin for low-light one- and two-photon inhibition of excitable cells.Science advances · 2022Article
- The Development and Application of Opto-Chemical Tools in the Zebrafish.Molecules (Basel, Switzerland) · 2022Review
- Long-term in vivo application of a potassium channel-based optogenetic silencer in the healthy and epileptic mouse hippocampus.BMC biology · 2022Article
- Deciphering Molecular Mechanisms and Intervening in Physiological and Pathophysiological Processes of CaCells · 2021Review
- Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.Pharmacological reviews · 2021Review
- Current Review of Optical Neural Interfaces for Clinical Applications.Micromachines · 2021Review
- Using a bistable animal opsin for switchable and scalable optogenetic inhibition of neurons.EMBO reports · 2021Article
- Microbial methionine transporters and biotechnological applications.Applied microbiology and biotechnology · 2021Review
- Optogenetic Modulation of Ion Channels by Photoreceptive Proteins.Advances in experimental medicine and biology · 2021Review
- Current Topics of Optogenetics for Medical Applications Toward Therapy.Advances in experimental medicine and biology · 2021Article
- Optical control of neuronal ion channels and receptors.Nature reviews. Neuroscience · 2019Review
- Engineered Passive Potassium Conductance in the KR2 Sodium Pump.Biophysical journal · 2019Article
- Potassium channel-based optogenetic silencing.Nature communications · 2018Article
- Global versus local mechanisms of temperature sensing in ion channels.Pflugers Archiv : European journal of physiology · 2018Review
- Light-Switchable Ion Channels and Receptors for Optogenetic Interrogation of Neuronal Signaling.Bioconjugate chemistry · 2018Review
- Optical Control of Dopamine Receptors Using a Photoswitchable Tethered Inverse Agonist.Journal of the American Chemical Society · 2017Article
- A high-conductance chemo-optogenetic system based on the vertebrate channel Trpa1b.Scientific reports · 2017Article
- Review
- Synapses in the spotlight with synthetic optogenetics.EMBO reports · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Genetically targeted light-activated ion channels and pumps make it possible to determine the role of specific neurons in neuronal circuits, information processing and behavior. We developed a K+-selective ionotropic glutamate receptor that reversibly inhibits neuronal activity in response to light in dissociated neurons and brain slice and also reversibly suppresses behavior in zebrafish. The receptor is a chimera of the pore region of a K+-selective bacterial glutamate receptor and the ligand-binding domain of a light-gated mammalian kainate receptor. This hyperpolarizing light-gated channel, HyLighter, is turned on by a brief light pulse at one wavelength and turned off by a pulse at a second wavelength. The control is obtained at moderate intensity. After optical activation, the photocurrent and optical silencing of activity persists in the dark for extended periods. The low light requirement and bi-stability of HyLighter represent advantages for the dissection of neural circuitry.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.