ReviewCurrent opinion in neurology2010
Update in restless legs syndrome.
Review in Current opinion in neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 85 citations in OpenAlex.
- Prospective study of restless legs syndrome and risk of depression in women.American journal of epidemiology · 2012Pooled it
- Prevalence of restless legs syndrome in North American and Western European populations: a systematic review.Sleep medicine · 2011Pooled it
- Yawning as Therapy? The Potential of the Conditioned Yawn Reflex as a Novel Treatment for Insomnia Disorder.Journal of sleep research · 2025Article
- Aripiprazole, a Novel Option in the Management of Restless Legs Syndrome (RLS) Patients with Augmentation and/or Severe RLS Symptoms: A Report of 4 Cases.Nature and science of sleep · 2023Article
- Management of restless legs syndrome in chronic liver disease: A challenge for the correct diagnosis and therapy.World journal of hepatology · 2018Article
- Non-headache symptoms in migraine patients.F1000Research · 2018Review
- Serum Ferritin Levels in Parkinson's Disease Patients with and without Restless Legs Syndrome.Movement disorders clinical practice · 2015Article
- Evaluation of temperament and character features as risk factors for depressive symptoms in patients with restless legs syndrome.Journal of clinical neurology (Seoul, Korea) · 2014Article
- Iron homeostasis in peripheral nervous system, still a black box?Antioxidants & redox signaling · 2014Review
- Treatment of restless legs syndrome.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2014Review
- Restless leg syndrome in different types of demyelinating neuropathies: a single-center pilot study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2013Article
- Human L-ferritin deficiency is characterized by idiopathic generalized seizures and atypical restless leg syndrome.The Journal of experimental medicine · 2013Article
- Restless legs syndrome: a comprehensive overview on its epidemiology, risk factors, and treatment.Sleep & breathing = Schlaf & Atmung · 2012Review
- Restless legs syndrome in multiple myeloma patients.Journal of clinical medicine research · 2012Article
- Association of multiple sclerosis with restless legs syndrome and other sleep disorders in women.Neurology · 2012Article
- Genetics of sleep and sleep disorders.Cell · 2011Review
- Ferritin overexpression in Drosophila glia leads to iron deposition in the optic lobes and late-onset behavioral defects.Neurobiology of disease · 2011Article
- Sleep disturbance and neurological disease.Clinical medicine (London, England) · 2011Review
- Article
- Prevalence and Clinical Characteristics of the Restless Legs Syndrome (RLS) in Patients Diagnosed with Attention-Deficit Hyperactivity Disorder (ADHD) in Antioquia.International journal of psychological researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
purpose of reviewAlthough restless legs syndrome (RLS) is a disorder recognized in the medical literature since the 17th century, there have only recently been significant clinical and scientific advances in diagnosis, epidemiology and understanding the disorder, mainly due to the advent of dopaminergic treatment. RECENT
findingsRecent discoveries have uncovered the iron-dopamine connection in RLS and the basic dopaminergic pathology related to the RLS symptoms. These have led to new understanding of the morbidity of RLS and the many conditions associated with RLS, which have also supported new approaches to treatment. These developments are each briefly described here. SUMMARY: Although there has been progress in understanding, diagnosing and treating RLS, it remains an underdiagnosed and undertreated condition severely impairing functioning of patients with moderate-to-severe disease. Much work is needed to improve on current, as well as other novel therapies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.