Evidence map›Paper›PMID 20581457›Full record

ReviewCell cycle (Georgetown, Tex.)2010

Long antisense non-coding RNAs and their role in transcription and oncogenesis.

Kevin V Morris, Peter K Vogt

Open access · bronzeAbstract readReview
In one paragraph

Review in Cell cycle (Georgetown, Tex.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 55 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Kevin V MorrisDepartment of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA. kmorris@scipps.edu
Peter K Vogt
Scripps Research Institute · US

Funding

Small Molecules and Targeted Gene Delivery in Tumor AngiogenesisP01CA078045 · NCI · SCRIPPS RESEARCH INSTITUTE, THE · PI VOGT, PETER K · 1998 to 2008
$10.2M
P3K, RETROVIRAL ONCOGENE AND HOMOLOG OF PI 3-KINASER01CA078230 · NCI · SCRIPPS RESEARCH INSTITUTE, THE · PI VOGT, PETER K · 1998 to 2013
$5.6M
Transcriptional Gene Silencing of HIV and CCR5R01HL083473 · NHLBI · SCRIPPS RESEARCH INSTITUTE, THE · PI MORRIS, KEVIN V · 2005 to 2009
$2.3M
Non-coding RNAs involved in HIV-1 LatencyR01AI084406 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI MORRIS, KEVIN V · 2009 to 2010
$889k
NCI NIH HHS P01 CA078045NCI NIH HHS P01 CA078045-10NCI NIH HHS R01 CA078230NCI NIH HHS R01 CA078230-12NHLBI NIH HHS R01 HL083473NHLBI NIH HHS R01 HL083473-02NIAID NIH HHS R01 AI084406NIAID NIH HHS R01 AI084406-02
6 · The paper itself

Abstract

Long non-coding RNAs are estimated to qualitatively represent ~98% of expressed transcripts in human cells, a large proportion of which is antisense to protein-coding and non-coding transcripts. Here we review evidence from several experimental systems that suggests long antisense non-coding RNAs are involved in the transcriptional regulation of gene expression by altering epigenetic states at both adjacent and distal loci. We also review the initial evidence for a role of endogenous long antisense non-coding RNAs in oncogenic cellular transformation.

Indexed as

Transcription, GeneticHumansModels, GeneticPrecancerous ConditionsRNA, AntisenseRNA, UntranslatedRNA, AntisenseRNA, Untranslated

Identifiers

PMID20581457
PMCPMC3040850
OpenAlexW1981033443

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.