ArticleEukaryotic cell2010
The Candida albicans ESCRT pathway makes Rim101-dependent and -independent contributions to pathogenesis.
Article in Eukaryotic cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Proteomic Analysis gives Novel Insights into Candida Albicans Morphogenesis in the Wake of Ubiquitin Mutation UbEP42.Cell biochemistry and biophysics · 2026Article
- Pitavastatin Calcium Confers Fungicidal Properties to Fluconazole by Inhibiting Ubiquinone Biosynthesis and Generating Reactive Oxygen Species.Antioxidants (Basel, Switzerland) · 2024Article
- Mathematical modeling of the Candida albicans yeast to hyphal transition reveals novel control strategies.PLoS computational biology · 2021Article
- The ESCRT System Plays an Important Role in the Germination in Candida albicans by Regulating the Expression of Hyphal-Specific Genes and the Localization of Polarity-Related Proteins.Mycopathologia · 2020Article
- The Role of Secretory Pathways inJournal of fungi (Basel, Switzerland) · 2020Review
- Candida albicansmBio · 2019Article
- A Novel Virulence Phenotype Rapidly AssessesmSphere · 2019Article
- Candida albicans Morphogenesis Programs Control the Balance between Gut Commensalism and Invasive Infection.Cell host & microbe · 2019Article
- A P4-ATPase subunit of the Cdc50 family plays a role in iron acquisition and virulence in Cryptococcus neoformans.Cellular microbiology · 2017Article
- Candida albicans cell-type switching and functional plasticity in the mammalian host.Nature reviews. Microbiology · 2017Review
- The AAA ATPase Vps4 Plays Important Roles in Candida albicans Hyphal Formation and is Inhibited by DBeQ.Mycopathologia · 2016Article
- Human Epithelial Cells Discriminate between Commensal and Pathogenic Interactions with Candida albicans.PloS one · 2016Article
- The endosomal sorting complex required for transport machinery influences haem uptake and capsule elaboration in Cryptococcus neoformans.Molecular microbiology · 2015Article
- pH signaling in human fungal pathogens: a new target for antifungal strategies.Eukaryotic cell · 2014Review
- Participation of Candida albicans transcription factor RLM1 in cell wall biogenesis and virulence.PloS one · 2014Article
- Candida albicans VMA3 is necessary for V-ATPase assembly and function and contributes to secretion and filamentation.Eukaryotic cell · 2013Article
- Rsr1 focuses Cdc42 activity at hyphal tips and promotes maintenance of hyphal development in Candida albicans.Eukaryotic cell · 2013Article
- Cryptococcus neoformans requires the ESCRT protein Vps23 for iron acquisition from heme, for capsule formation, and for virulence.Infection and immunity · 2013Article
- The β-arrestin-like protein Rim8 is hyperphosphorylated and complexes with Rim21 and Rim101 to promote adaptation to neutral-alkaline pH.Eukaryotic cell · 2012Article
- Mouse model of oropharyngeal candidiasis.Nature protocols · 2012Article
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4 authors.
Funding
Abstract
Candida albicans is an opportunistic pathogen that colonizes diverse mucosal niches with distinct environmental characteristics. To adapt to these different sites, C. albicans must activate and attenuate a variety of signal transduction pathways. A mechanism of signal attenuation is through receptor endocytosis and subsequent vacuolar degradation, which requires the endosomal sorting complex required for transport (ESCRT) pathway. This pathway comprises several polyprotein complexes (ESCRT-0, -I, -II, -III, and -DS) that are sequentially recruited to the endosomal membrane. The ESCRT pathway also activates the Rim101 transcription factor, which governs expression of genes required for virulence. Here, we tested the hypothesis that the ESCRT pathway plays a Rim101-independent role(s) in pathogenesis. We generated deletion mutants in each ESCRT complex and determined that ESCRT-I, -II, and -III are required for Rim101 activation but that ESCRT-0 and ESCRT-DS are not. We found that the ESCRT-0 member Vps27 and ESCRT-DS components are required to promote epithelial cell damage and, using a murine model of oral candidiasis, found that the vps27Delta/Delta mutant had a decreased fungal burden compared to that of the wild type. We found that a high-dose inoculum can compensate for fungal burden defects but that mice colonized with the vps27Delta/Delta strain exhibit less morbidity than do mice infected with the wild-type strain. These results demonstrate that the ESCRT pathway has Rim101-independent functions for C. albicans virulence.
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