ArticleGut2010
Conditional Gata4 deletion in mice induces bile acid absorption in the proximal small intestine.
Article in Gut, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 45 citations in OpenAlex.
- Sodium Butyrate Ameliorated Bile Acid Metabolism in Diabetes Mellitus by PI3K/AKT Signaling Pathway via the Gut-Liver Axis.Current issues in molecular biology · 2025Article
- Novel Expression of Apical Bile Acid Transport (ASBT) More Proximally Than Distal Ileum Contributing to Enhanced Intestinal Bile Acid Absorption in Obesity.International journal of molecular sciences · 2024Article
- Active enterohepatic cycling is not required for the choleretic actions of 24-norUrsodeoxycholic acid in mice.JCI insight · 2023Article
- Interactive Relationships between Intestinal Flora and Bile Acids.International journal of molecular sciences · 2022Review
- Structure-function analysis of purified proanthocyanidins reveals a role for polymer size in suppressing inflammatory responses.Communications biology · 2021Article
- Intestinal Absorption of Bile Acids in Health and Disease.Comprehensive Physiology · 2019Review
- Differences in DNA Methylation and Functional Expression in Lactase Persistent and Non-persistent Individuals.Scientific reports · 2018Article
- Patterning the gastrointestinal epithelium to confer regional-specific functions.Developmental biology · 2018Review
- Organic Solute Transporter α-β Protects Ileal Enterocytes From Bile Acid-Induced Injury.Cellular and molecular gastroenterology and hepatology · 2018Article
- Differentiation of Human Pluripotent Stem Cells into Colonic Organoids via Transient Activation of BMP Signaling.Cell stem cell · 2017Article
- Gata4 is critical to maintain gut barrier function and mucosal integrity following epithelial injury.Scientific reports · 2016Article
- The emerging role of GATA transcription factors in development and disease.Expert reviews in molecular medicine · 2016Review
- Oral treatment withNPJ biofilms and microbiomes · 2016Article
- Gut microbiota inhibit Asbt-dependent intestinal bile acid reabsorption via Gata4.Journal of hepatology · 2015Article
- An integrative view of microbiome-host interactions in inflammatory bowel diseases.Cell host & microbe · 2015Review
- Effect of Roux-en-Y gastric bypass surgery on bile acid metabolism in normal and obese diabetic rats.PloS one · 2015Article
- GATA4 represses an ileal program of gene expression in the proximal small intestine by inhibiting the acetylation of histone H3, lysine 27.Biochimica et biophysica acta · 2014Article
- Epigenetic modulation of intestinal cholesterol transporter Niemann-Pick C1-like 1 (NPC1L1) gene expression by DNA methylation.The Journal of biological chemistry · 2014Article
- Role of GATA factors in development, differentiation, and homeostasis of the small intestinal epithelium.American journal of physiology. Gastrointestinal and liver physiology · 2014Review
- Spdef deletion rescues the crypt cell proliferation defect in conditional Gata6 null mouse small intestine.BMC molecular biology · 2014Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
aimsThe transcription factor GATA4 is expressed throughout most of the small intestine except distal ileum, and restricts expression of the apical sodium-dependent bile acid transporter (ASBT), the rate-limiting intestinal bile acid transporter, to distal ileum. The hypothesis was tested that reduction of GATA4 activity in mouse small intestine results in an induction of bile acid transport in proximal small intestine sufficient to restore bile acid absorption and homeostasis after ileocaecal resection (ICR).
methodsBile acid homeostasis was characterised in non-surgical, sham or ICR mice using two recombinant Gata4 models in which Asbt expression is induced to different levels.
resultsReduction of intestinal GATA4 activity resulted in an induction of ASBT expression, bile acid absorption and expression of bile acid-responsive genes in proximal small intestine, and a reduction of luminal bile acids in distal small intestine. While faecal bile acid excretion and bile acid pool size remained unchanged, the bile acid pool became more hydrophilic due to a relative increase in tauro-beta-muricholate absorption. Furthermore, proximal induction of Asbt in both Gata4 mutant models corrected ICR-associated bile acid malabsorption, reversing the decrease in bile acid pool size and increase in faecal bile acid excretion and hepatic cholesterol 7alpha-hydroxylase expression.
conclusionsReduction of intestinal GATA4 activity induces bile acid absorption in proximal small intestine without inducing major changes in bile acid homeostasis. This induction is sufficient to correct bile acid malabsorption caused by ICR in mice.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.