ArticleJournal of bacteriology2010
The pdh operon is expressed in a subpopulation of stationary-phase bacteria and is important for survival of sugar-starved Streptococcus mutans.
Article in Journal of bacteriology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Transcriptomic response in planktonic and biofilm-associated cells of Streptococcus mutans treated with sublethal concentrations of chlorhexidine.FEMS microbiology letters · 2025Article
- Small RNA SmsR1 modulates acidogenicity and cariogenic virulence by affecting protein acetylation in Streptococcus mutans.PLoS pathogens · 2024Article
- Genetic characterization of glyoxalase pathway in oral streptococci and its contribution to interbacterial competition.Journal of oral microbiology · 2024Article
- Anti-Bacterial and Anti-Biofilm Activities of Anandamide against the CariogenicInternational journal of molecular sciences · 2023Article
- Drug sensitivity and genome-wide analysis of two strains ofFrontiers in microbiology · 2023Article
- Inhibitory effects of Stevioside onFrontiers in microbiology · 2023Article
- Disruption of theJournal of bacteriology · 2022Article
- Spontaneous Mutants of Streptococcus sanguinis with Defects in the Glucose-Phosphotransferase System Show Enhanced Post-Exponential-Phase Fitness.Journal of bacteriology · 2021Article
- Acetate and Potassium Modulate the Stationary-Phase Activation ofFrontiers in microbiology · 2020Article
- Inhibitory effect of surface pre-reacted glass-ionomer (S-PRG) eluate against adhesion and colonization by Streptococcus mutans.Scientific reports · 2018Article
- Modification of theMicrobial genomics · 2017Article
- Molecular Basis of Stationary Phase Survival and Applications.Frontiers in microbiology · 2017Review
- RNA-Seq Reveals Enhanced Sugar Metabolism inFrontiers in microbiology · 2017Article
- O-mannosylation in Candida albicans enables development of interkingdom biofilm communities.mBio · 2014Article
- Mucin can enhance growth, biofilm formation, and survival of Streptococcus mutans.FEMS microbiology letters · 2014Article
- Replicating DNA by cell factories: roles of central carbon metabolism and transcription in the control of DNA replication in microbes, and implications for understanding this process in human cells.Microbial cell factories · 2013Review
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Authors and funding
3 authors.
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Abstract
Streptococcus mutans is a facultative member of the oral plaque and is associated with dental caries. It is able to survive long periods of sugar starvation. We show here that inactivation of pdhD, putatively encoding a subunit of the pyruvate dehydrogenase complex, impairs survival of both batch cultures and biofilms. We show that pdhD and the downstream genes pdhA, pdhB, and pdhC form an operon that is predominantly transcribed in stationary phase. Analysis with fluorescent reporters revealed a bimodal expression pattern for the pdh promoter, with less than 1% of stationary-phase populations expressing pdh. When it was first detected, after 1 day of sugar starvation in batch culture, expression was mostly in individual bacteria. At later times, expressing bacteria were often in chains. The lengths of the chains increased with time. We infer that the pdh-expressing subpopulation is able grow and divide and to persist for extended times in stationary phase.
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