ArticleApplied and environmental microbiology2010
Molecular and genetic analyses of the putative Proteus O antigen gene locus.
Article in Applied and environmental microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 19 citations in OpenAlex.
- Augmented Enterocyte Damage DuringFrontiers in cellular and infection microbiology · 2022Article
- Draft Genome ofFrontiers in cellular and infection microbiology · 2021Article
- Cell Shape and Population Migration Are Distinct Steps ofJournal of bacteriology · 2019Article
- Genetic diversity of the O antigens of Proteus species and the development of a suspension array for molecular serotyping.PloS one · 2017Article
- Functional identification of Proteus mirabilis eptC gene encoding a core lipopolysaccharide phosphoethanolamine transferase.International journal of molecular sciences · 2014Article
- MoeH5: a natural glycorandomizer from the moenomycin biosynthetic pathway.Molecular microbiology · 2013Article
- Three enzymatic steps required for the galactosamine incorporation into core lipopolysaccharide.The Journal of biological chemistry · 2010Article
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proteus species are well-characterized opportunistic pathogens primarily associated with urinary tract infections (UTI) of humans. The Proteus O antigen is one of the most variable constituents of the cell surface, and O antigen heterogeneity is used for serological classification of Proteus isolates. Even though most Proteus O antigen structures have been identified, the O antigen locus has not been well characterized. In this study, we identified the putative Proteus O antigen locus and demonstrated this region's high degree of heterogeneity by comparing sequences of 40 Proteus isolates using PCR-restriction fragment length polymorphism (RFLP). This analysis identified five putative Proteus O antigen gene clusters, and the probable functions of these O antigen-related genes were proposed, based on their similarity to genes in the available databases. Finally, Proteus-specific genes from these five serogroups were identified by screening 79 strains belonging to the 68 Proteus O antigen serogroups. To our knowledge, this is the first molecular characterization of the putative Proteus O antigen locus, and we describe a novel molecular classification method for the identification of different Proteus serogroups.
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