ArticleThe Journal of heredity
Functional genomics of physiological plasticity and local adaptation in killifish.
Article in The Journal of heredity. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 110 citations in OpenAlex.
- Neighboring Gulf Killifish (Ecology and evolution · 2026Article
- Transcriptomic Response and Molecular Adaptation Mechanisms of Common Carp (Animals : an open access journal from MDPI · 2026Article
- The population genetics of convergent adaptation in maize and teosinte is not locally restricted.eLife · 2025Article
- Comparative Transcriptomic Analyses Reveal Differences in the Responses of Diploid and Triploid Eastern Oysters to Environmental Stress.Evolutionary applications · 2024Article
- Genome scans reveal signals of selection associated with pollution in fish populations of Basilichthys microlepidotus, an endemic species of Chile.Scientific reports · 2024Article
- Disturbance of oxidation/antioxidant status and histopathological damage in tsinling lenok trout under acute thermal stress.Tropical animal health and production · 2023Article
- Whole-genome Analyses Reveal Past Population Fluctuations and Low Genetic Diversities of the North Pacific Albatrosses.Molecular biology and evolution · 2023Article
- Transcriptomic Response of the Liver Tissue inAnimals : an open access journal from MDPI · 2023Article
- Effect of climate change on hematotoxicity/hepatoxicity oxidative stress, Oncorhynchus mykiss, under controlled conditions.PloS one · 2023Article
- Article
- Is aquaporin-3 involved in water-permeability changes in the killifish during hypoxia and normoxic recovery, in freshwater or seawater?Journal of experimental zoology. Part A, Ecological and integrative physiology · 2020Article
- Draft genome assembly of Tenualosa ilisha, Hilsa shad, provides resource for osmoregulation studies.Scientific reports · 2019Article
- The osmorespiratory compromise in the euryhaline killifish: water regulation during hypoxia.The Journal of experimental biology · 2019Article
- Comparative transcriptomics of 3 high-altitude passerine birds and their low-altitude relatives.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Evolutionary Toxicogenomics of the Striped Killifish (International journal of molecular sciences · 2019Article
- Netting the Stress Responses in Fish.Frontiers in endocrinology · 2019Review
- Arsenic Reduces Gene Expression Response to Changing Salinity in Killifish.Environmental science & technology · 2018Article
- Transcriptomic differentiation underlying marine-to-freshwater transitions in the South American silversidesEcology and evolution · 2017Article
- The landscape of extreme genomic variation in the highly adaptable Atlantic killifish.Genome biology and evolution · 2017Article
- Long-Term Overgrazing-Induced Memory Decreases Photosynthesis of Clonal Offspring in a Perennial Grassland Plant.Frontiers in plant science · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Evolutionary solutions to the physiological challenges of life in highly variable habitats can span the continuum from evolution of a cosmopolitan plastic phenotype to the evolution of locally adapted phenotypes. Killifish (Fundulus sp.) have evolved both highly plastic and locally adapted phenotypes within different selective contexts, providing a comparative system in which to explore the genomic underpinnings of physiological plasticity and adaptive variation. Importantly, extensive variation exists among populations and species for tolerance to a variety of stressors, and we exploit this variation in comparative studies to yield insights into the genomic basis of evolved phenotypic variation. Notably, species of Fundulus occupy the continuum of osmotic habitats from freshwater to marine and populations within Fundulus heteroclitus span far greater variation in pollution tolerance than across all species of fish. Here, we explore how transcriptome regulation underpins extreme physiological plasticity on osmotic shock and how genomic and transcriptomic variation is associated with locally evolved pollution tolerance. We show that F. heteroclitus quickly acclimate to extreme osmotic shock by mounting a dramatic rapid transcriptomic response including an early crisis control phase followed by a tissue remodeling phase involving many regulatory pathways. We also show that convergent evolution of locally adapted pollution tolerance involves complex patterns of gene expression and genome sequence variation, which is confounded with body-weight dependence for some genes. Similarly, exploiting the natural phenotypic variation associated with other established and emerging model organisms is likely to greatly accelerate the pace of discovery of the genomic basis of phenotypic variation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.