ArticleJournal of lipid research2010
Gene-environment interactions of CETP gene variation in a high cardiovascular risk Mediterranean population.
Article in Journal of lipid research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- CETP genotype and changes in lipid levels in response to weight-loss diet intervention in the POUNDS LOST and DIRECT randomized trials.Journal of lipid research · 2015Trial
- One Diet Does Not Fit All: A Systematic Review and Meta-Analysis of Gene-Diet Interactions Affecting Blood Lipid Profiles.Current issues in molecular biology · 2026Review
- Cholesterol Ester Transfer ProteinIranian journal of medical sciences · 2024Article
- Dietary antioxidant status indices may not interact with CETP Taq1B polymorphism on lipid profile and severity of coronary artery stenosis in patients under coronary angiography.Food science & nutrition · 2024Article
- Interaction between CETP Taq1B polymorphism and dietary patterns on lipid profile and severity of coronary arteries stenosis in patients under coronary angiography: a cross-sectional study.Nutrition journal · 2023Article
- A Nutrigenetic Update on CETP Gene-Diet Interactions on Lipid-Related Outcomes.Current atherosclerosis reports · 2022Review
- Interaction between CETP polymorphism and dietary insulin index and load in relation to cardiovascular risk factors in diabetic adults.Scientific reports · 2021Article
- The combined effects of cholesteryl ester transfer protein (Journal of cardiovascular and thoracic research · 2020Article
- Deciphering the Riddles in Nutrition and Cardiovascular Disease.European cardiology · 2019Review
- Nutrition and Cardiovascular Health.International journal of molecular sciences · 2018Review
- Genetic variations of cholesteryl ester transfer protein and diet interactions in relation to lipid profiles and coronary heart disease: a systematic review.Nutrition & metabolism · 2017Review
- Impact of variants in CETP and apo AI genes on serum HDL cholesterol levels in men and women from the Polish population.Archives of medical science : AMS · 2016Article
- Advances in Integrating Traditional and Omic Biomarkers When Analyzing the Effects of the Mediterranean Diet Intervention in Cardiovascular Prevention.International journal of molecular sciences · 2016Review
- MicroRNAs and Drinking: Association between the Pre-miR-27a rs895819 Polymorphism and Alcohol Consumption in a Mediterranean Population.International journal of molecular sciences · 2016Article
- Mediterranean diet and cardiovascular health: Teachings of the PREDIMED study.Advances in nutrition (Bethesda, Md.) · 2014Review
- Omega-3 fatty acids, polymorphisms and lipid related cardiovascular disease risk factors in the Inuit population.Nutrition & metabolism · 2013Article
Corrections and comments
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Authors and funding
16 authors at 10 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genome-wide association studies show that cholesteryl ester transfer protein (CETP) single nucleotide polymorphisms (SNPs) are more strongly associated with HDL cholesterol (HDL-C) concentrations than any other loci across the genome. However, gene-environment interactions for clinical applications are still largely unknown. We studied gene-environment interactions between CETP SNPs and dietary fat intake, adherence to the Mediterranean diet, alcohol consumption, smoking, obesity, and diabetes on HDL-C in 4,210 high cardiovascular risk subjects from a Mediterranean population. We focused on the -4,502C>T and the TaqIB SNPs in partial linkage disequilibrium (D'= 0.88; P < 0.001). They were independently associated with higher HDL-C (P < 0.001); this clinically relevant association was greater when their diplotype was considered (14% higher in TT/B2B2 vs. CC/B1B1). No gene-gene interaction was observed. We also analyzed the association of these SNPs with blood pressure, and no clinically relevant associations were detected. No statistically significant interactions of these SNPs with obesity, diabetes, and smoking in determining HDL-C concentrations were found. Likewise, alcohol, dietary fat, and adherence to the Mediterranean diet did not statistically interact with the CETP variants (independently or as diplotype) in determining HDL-C. In conclusion, the strong association of the CETP SNPs and HDL-C was not statistically modified by diet or by the other environmental factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.