ArticleThe American journal of pathology2010
Novel molecular imaging approach for subclinical detection of iritis and evaluation of therapeutic success.
Article in The American journal of pathology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- In contrast to Western diet, a plant-based, high-fat, low-sugar diet does not exacerbate retinal endothelial injury in streptozotocin-induced diabetes.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Cathepsin B-mediated CD18 shedding regulates leukocyte recruitment from angiogenic vessels.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
- Molecular imaging reveals elevated VEGFR-2 expression in retinal capillaries in diabetes: a novel biomarker for early diagnosis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- Anti-inflammatory effects of cannabinoid CB(2) receptor activation in endotoxin-induced uveitis.British journal of pharmacology · 2014Article
- Vascular adhesion protein 1 in the eye.Journal of ophthalmology · 2013Article
- Noninvasive molecular imaging reveals role of PAF in leukocyte-endothelial interaction in LPS-induced ocular vascular injury.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2011Article
- VAP-1-mediated M2 macrophage infiltration underlies IL-1β- but not VEGF-A-induced lymph- and angiogenesis.The American journal of pathology · 2011Article
- Molecular Imaging of Subclinical Diabetic Retinopathy.Journal of ophthalmic & vision researchArticle
- Molecular Imaging of Retinal Endothelial Injury in Diabetic Animals.Journal of ophthalmic & vision researchArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
There is an urgent need for early diagnosis in medicine, whereupon effective treatments could prevent irreversible tissue damage. Acute anterior chamber inflammation is the most common form of uveitis and a major cause of vision loss. The proximity of the iris vasculature to the light-permeable cornea and its involvement in ocular inflammation make it an ideal target for noninvasive molecular imaging. To accomplish this, carboxylated fluorescent microspheres (MSs) were conjugated with recombinant P-selectin glycoprotein ligand-1 and systemically injected in endotoxin-induced uveitic animals. MS adhesion in the microcirculation of the anterior and posterior chamber was visualized by intravital microscopy and scanning laser ophthalmoscopy. In iritic animals, significantly higher numbers of recombinant P-selectin glycoprotein ligand-1-conjugated MSs adhered to the endothelium (P = 0.03) matching the increase in leukocyte adhesion. Conjugated MSs specifically interacted with firmly adhering leukocytes, allowing quantification of the endogenous immune response. Topical eye drop treatment with dexamethasone (P < 0.01) or cyclosporine A (P < 0.01) significantly lowered MS adhesion in iris vessels. Surprisingly, topical dexamethasone significantly reduced MS interaction in the fundus vessels (P < 0.01), while cyclosporine A did not. In vivo MS accumulation preceded clinical signs of anterior uveitis and leukocyte adhesion in iris vasculature. This work introduces noninvasive subclinical detection of endothelial injury in the iris vasculature, providing a unique opportunity for quantifying vascular injury and immune response in vivo.
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Registered trials
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