ArticleHearing research2010
Modeling the electrode-neuron interface of cochlear implants: effects of neural survival, electrode placement, and the partial tripolar configuration.
Article in Hearing research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
73 citing papers in PubMed, 132 citations in OpenAlex.
- Initial Results With Image-guided Cochlear Implant Programming in Children.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2016Trial
- Electrode spanning with partial tripolar stimulation mode in cochlear implants.Journal of the Association for Research in Otolaryngology : JARO · 2014Trial
- Asymmetric temporal envelope encoding: Lateralization with varying envelope shape and spectral mismatch.The Journal of the Acoustical Society of America · 2025Article
- A comparison of electrophysiological measures for characterizing the cochlear-implant electrode-neuron interface.JASA express letters · 2025Article
- Axon initial segment plasticity caused by auditory deprivation degrades time difference sensitivity in a model of neural responses to cochlear implants.Journal of computational neuroscience · 2025Article
- Cochlear-implant simulated spectral degradation attenuates emotional responses to environmental sounds.International journal of audiology · 2025Article
- Model-Based Inference of Electrode Distance and Neuronal Density from Measured Detection Thresholds in Cochlear Implant Listeners.Journal of the Association for Research in Otolaryngology : JARO · 2025Article
- Investigating the Effect of Blurring and Focusing Current in Cochlear Implant Users with the Panoramic ECAP Method.Journal of the Association for Research in Otolaryngology : JARO · 2024Article
- Speech-evoked cortical activities and speech recognition in adult cochlear implant listeners: a review of functional near-infrared spectroscopy studies.Experimental brain research · 2024Review
- Effects of selective stimulation of apical electrodes on temporal pitch perception by cochlear implant recipients.The Journal of the Acoustical Society of America · 2024Article
- The geometry of photopolymerized topography influences neurite pathfinding by directing growth cone morphology and migration.Journal of neural engineering · 2024Article
- Exploring the Use of Interleaved Stimuli to Measure Cochlear-Implant Excitation Patterns.Journal of the Association for Research in Otolaryngology : JARO · 2024Article
- Effects of the Number of Channels and Channel Stimulation Rate on Speech Recognition and Sound Quality Using Precurved Electrode Arrays.American journal of audiology · 2023Article
- What Is the Benefit of Ramped Pulse Shapes for Activating Auditory Cortex Neurons? An Electrophysiological Study in an Animal Model of Cochlear Implant.Brain sciences · 2023Article
- Speech recognition as a function of the number of channels for pediatric cochlear implant recipients.JASA express letters · 2022Article
- Recent Advances in Cochlear Implant Electrode Array Design Parameters.Micromachines · 2022Review
- Model-based prediction of optogenetic sound encoding in the human cochlea by future optical cochlear implants.Computational and structural biotechnology journal · 2022Article
- Effects of Degrees of Degeneration on the Electrical Excitation of Human Spiral Ganglion Neurons Based on a High-Resolution Computer Model.Frontiers in neuroscience · 2022Article
- The Panoramic ECAP Method: Estimating Patient-Specific Patterns of Current Spread and Neural Health in Cochlear Implant Users.Journal of the Association for Research in Otolaryngology : JARO · 2021Review
- Cochlear Implant Research and Development in the Twenty-first Century: A Critical Update.Journal of the Association for Research in Otolaryngology : JARO · 2021Review
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The partial tripolar electrode configuration is a relatively novel stimulation strategy that can generate more spatially focused electric fields than the commonly used monopolar configuration. Focused stimulation strategies should improve spectral resolution in cochlear implant users, but may also be more sensitive to local irregularities in the electrode-neuron interface. In this study, we develop a practical computer model of cochlear implant stimulation that can simulate neural activation in a simplified cochlear geometry and we relate the resulting patterns of neural activity to basic psychophysical measures. We examine how two types of local irregularities in the electrode-neuron interface, variations in spiral ganglion nerve density and electrode position within the scala tympani, affect the simulated neural activation patterns and how these patterns change with electrode configuration. The model shows that higher partial tripolar fractions activate more spatially restricted populations of neurons at all current levels and require higher current levels to excite a given number of neurons. We find that threshold levels are more sensitive at high partial tripolar fractions to both types of irregularities, but these effects are not independent. In particular, at close electrode-neuron distances, activation is typically more spatially localized which leads to a greater influence of neural dead regions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.