ArticleDevelopmental biology2010
A compartmental model for the bicoid gradient.
Article in Developmental biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Pseudocleavage furrows restrict plasma membrane-associated PH domain in syncytial Drosophila embryos.Biophysical journal · 2022Article
- Article
- Self-Similar Dynamics of Nuclear Packing in the Early Drosophila Embryo.Biophysical journal · 2019Article
- Two-Exponential Models of Gene Expression Patterns for Noisy Experimental Data.Journal of computational biology : a journal of computational molecular cell biology · 2018Article
- Bicoid gradient formation mechanism and dynamics revealed by protein lifetime analysis.Molecular systems biology · 2018Article
- Semi-permeable Diffusion Barriers Enhance Patterning Robustness in the C. elegans Germline.Developmental cell · 2015Article
- Morphogen transport.Development (Cambridge, England) · 2013Article
- Torso RTK controls Capicua degradation by changing its subcellular localization.Development (Cambridge, England) · 2012Article
- The synthesis-diffusion-degradation model explains Bicoid gradient formation in unfertilized eggs.Physical biology · 2012Article
- Mathematics and biology: a Kantian view on the history of pattern formation theory.Development genes and evolution · 2011Review
- The role of regulated mRNA stability in establishing bicoid morphogen gradient in Drosophila embryonic development.PloS one · 2011Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The anterior region of the Drosophila embryo is patterned by the concentration gradient of the homeodomain transcription factor bicoid (Bcd). The Bcd gradient was the first identified morphogen gradient and continues to be a subject of intense research at multiple levels, from the mechanisms of RNA localization in the oocyte to the evolution of the Bcd-mediated patterning events in multiple Drosophila species. Critical assessment of the mechanisms of the Bcd gradient formation requires biophysical models of the syncytial embryo. Most of the proposed models rely on reaction-diffusion equations, but their formulation and applicability at high nuclear densities is a nontrivial task. We propose a straightforward alternative in which the syncytial blastoderm is approximated by a periodic arrangement of well-mixed compartments: a single nucleus and an associated cytoplasmic region. We formulate a compartmental model, constrain its parameters by experimental data, and demonstrate that it provides an adequate description of the Bcd gradient dynamics.
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