Evidence map›Paper›PMID 20580599›Full record

ReviewCurrent opinion in microbiology2010

Composition and sensory function of the trypanosome flagellar membrane.

Danijela Maric, Conrad L Epting, David M Engman

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 35 citations in OpenAlex.

  1. New Vistas in the Biology of the Flagellum-Pathogens (Basel, Switzerland) · 2022
    Review
  2. Article
  3. Article
  4. Review
  5. Transport of Ciliary Membrane Proteins.Frontiers in cell and developmental biology · 2019
    Review
  6. Article
  7. TheThe Journal of biological chemistry · 2017
    Article
  8. Article
  9. Ciliary Extracellular Vesicles: Txt Msg Organelles.Cellular and molecular neurobiology · 2016
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Regulation and biological function of a flagellar glucose transporter in Leishmania mexicana: a potential glucose sensor.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015
    Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Danijela MaricDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Conrad L Epting
David M Engman
Northwestern University · US

Funding

TRYPANOSOME FLAGELLAR CALCIUM ACYL SWITCH PROTEINSR01AI046781 · NIAID · NORTHWESTERN UNIVERSITY · PI ENGMAN, DAVID M. · 2000 to 2004
$1.7M
Structure and Function of the Trypanosome Flagellar MembraneR01GM093359 · NIGMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ENGMAN, DAVID M. · 2010 to 2013
$1.2M
NIAID NIH HHS R01 AI046781NIGMS NIH HHS R01 GM093359
6 · The paper itself

Abstract

A cilium is an extension of the cell that contains an axonemal complex of microtubules and associated proteins bounded by a membrane which is contiguous with the cell body membrane. Cilia may be nonmotile or motile, the latter having additional specific roles in cell or fluid movement. The term flagellum refers to the motile cilium of free-living single cells (e.g. bacteria, archaea, spermatozoa, and protozoa). In eukaryotes, both nonmotile and motile cilia possess sensory functions. The ciliary interior (cilioplasm) is separated from the cytoplasm by a selective barrier that prevents passive diffusion of molecules between the two domains. The sensory functions of cilia reside largely in the membrane and signals generated in the cilium are transduced into a variety of cellular responses. In this review we discuss the structure and biogenesis of the cilium, with special attention to the trypanosome flagellar membrane, its lipid and protein composition and its proposed roles in sensing and signaling.

Indexed as

AnimalsCell MembraneCiliaFlagellaHumansLipidsProtozoan ProteinsSignal TransductionTrypanosomaLipidsProtozoan Proteins

Identifiers

PMID20580599
PMCPMC2920355
OpenAlexW2022658325

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.