Evidence map›Paper›PMID 20580201›Full record

Trial reportJournal of pain and symptom management2010

The association of depression and pain with health-related quality of life, disability, and health care use in cancer patients.

Kurt Kroenke, Dale Theobald, Jingwei Wu, Julie K Loza, Janet S Carpenter, Wanzhu Tu

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of pain and symptom management, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07167056 (Artificial Intelligence-Powered Support For Quality Of Life Improvement In Patients With Cancer), which is not on this map. Cited by 109 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed, 6 pooled it
10.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07167056 narecruitingnot on this mapstarted 2025, after this paper: background citation

Artificial Intelligence-Powered Support For Quality Of Life Improvement In Patients With Cancer

TypeinterventionalSponsorCase Comprehensive Cancer CenterRan2025 to 2027Enrolled60ConditionsCancerArmsStandard of Care Psychotherapy, WYSA App
3 · Its place in the literature

Who cites it

109 citing papers in PubMed, 6 syntheses or guidelines pooled it, 253 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Efficacy of pain education in cancer patients: a meta-analysis of randomized controlled trials.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2013
    Pooled it
  4. Pooled it
  5. Collaborative care for depression and anxiety problems.The Cochrane database of systematic reviews · 2012
    Pooled it
  6. Pooled it
  7. The effect of the Emotional Freedom Technique (EFT) on pain and depression in cancer patients: a randomized controlled trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Trial
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  9. Clinical pharmacist interventions on pain management in cancer patients (PharmaCAP) in low resource settings: a multicenter feasibility-pilot randomized controlled trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Trial
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  17. Opioid prescribing patterns at the end of life in an asian advanced cancer cohort: differences by palliative care consultation status.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  18. Pain interfering with daily life in patients with cancer: stronger associations with anxiety and emotional distress than with pain intensity.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Observational
  19. Article
  20. Review

49 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Kurt KroenkeRegenstrief Institute, Inc., 1050 Wishard Blvd., 6th Floor, Indianapolis, IN 46202, USA. kkroenke@regenstrief.org
Dale Theobald
Jingwei Wu
Julie K Loza
Janet S Carpenter
Wanzhu Tu
Indiana University – Purdue University Indianapolis · USRegenstrief Institute · USUniversity of Southern Indiana · US

Funding

TeleCare Management of Pain and Depression in CancerR01CA115369 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI KROENKE, KURT · 2005 to 2009
$2.1M
NCI NIH HHS R01 CA-115369NCI NIH HHS R01 CA115369
6 · The paper itself

Abstract

contextPain and depression are two of the most prevalent and treatable cancer-related symptoms, each present in at least 20%-30% of oncology patients.

objectiveTo determine the associations of pain and depression with health-related quality of life (HRQL), disability, and health care use in cancer patients.

methodsThe Indiana Cancer Pain and Depression study is a randomized clinical trial comparing telecare management vs. usual care for patients with cancer-related pain and/or clinically significant depression. In this article, baseline data on patients enrolled from 16 urban or rural community-based oncology practices are analyzed to test the associations of pain and depression with HRQL, disability, and health care use.

resultsOf the 405 participants, 32% had depression only, 24% pain only, and 44% both depression and pain. The average Hopkins Symptom Checklist 20-item depression score in the 309 depressed participants was 1.64 (on 0-4 scale), and the average Brief Pain Inventory (BPI) severity score in the 274 participants with pain was 5.2 (on 0-10 scale), representing at least moderate levels of symptom severity. Symptom-specific disability was high, with participants reporting an average of 16.8 of the past 28 days (i.e., 60% of their days in the past four weeks) in which they were either confined to bed (5.6 days) or had to reduce their usual activities by 50% (11.2 days) because of pain or depression. Moreover, 176 (43%) participants reported being unable to work because of health-related reasons. Depression and pain had both individual and additive adverse associations with quality of life. Most patients were currently not receiving care from a mental health or pain specialist.

conclusionDepression and pain are prevalent and disabling across a wide range of types and phases of cancer, commonly co-occur, and have additive adverse effects. Enhanced detection and management of this disabling symptom dyad is warranted.

Indexed as

Disability EvaluationQuality of LifeAgedAnalgesicsAntidepressive AgentsDepressionFemaleHealth ResourcesHumansIndianaMaleMiddle AgedNeoplasmsPainPain MeasurementPsychiatric Status Rating ScalesAnalgesicsAntidepressive Agents

Identifiers

PMID20580201
PMCPMC2934745
OpenAlexW1972842876

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.