Migration of dendritic cells from murine skeletal muscle.

Lei Wang, Saman Eghtesad, Paula R Clemens

Abstract readComparative Study

In one paragraph

Article in Immunobiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.1field-weighted citation impact, top 47% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

Extracellular vesicles are key mediators for direct antigen transport to draining lymph nodes.Molecular therapy : the journal of the American Society of Gene Therapy · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Lei WangDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA.

Saman Eghtesad

Paula R Clemens

University of Pittsburgh · US

Funding

Inducing Tolerance to Gene Transfer in Dystrophic MiceF31NS056780 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI EGHTESAD, SAMAN · 2008 to 2010

$111k

NINDS NIH HHS 1-F31-NS056780-01A2NINDS NIH HHS F31 NS056780

6 · The paper itself

Abstract

To better understand the role of dendritic cells (DCs) in skeletal muscle, we investigated the migration of DCs from murine skeletal muscle and compared that to previously studied footpad (FP) DC trafficking. We adoptively transferred carboxyfluorescein diacetate succinimidyl ester (CFSE)-labeled mature DCs to syngeneic mice and followed them in various lymphatic tissues at different time points. Injection of DCs into the tibialis anterior muscle resulted in the peak number of CFSE(+) DCs recovered in spleen at 12h, not at 24h, when the largest number of these cells appeared in the draining lymph nodes. Interestingly, this result for adoptive transfer of DCs to skeletal muscle differs with what is previously reported for adoptive transfer to the FP, a result that we also confirmed in parallel studies. These findings could have a significant impact on (1) understanding muscle diseases with immunological complications such as muscular dystrophies and (2) the immunologic effects of treatments for muscle diseases.

Indexed as

Immunotherapy, AdoptiveAdoptive TransferAnimalsBone MarrowCell MovementCells, CulturedDendritic CellsDisease Models, AnimalFluoresceinsFootHumansMiceMice, Inbred C57BLMuscle, SkeletalMuscular DystrophiesSuccinimides5-(6)-carboxyfluorescein diacetate succinimidyl esterFluoresceinsSuccinimides

Identifiers

PMID20580121

DOI10.1016/j.imbio.2010.04.006

PMCPMC2974789

OpenAlexW2083615628

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.