ArticleBiological psychiatry2010
Brain mu-opioid receptor binding predicts treatment outcome in cocaine-abusing outpatients.
Article in Biological psychiatry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 65 citations in OpenAlex.
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- Opposing neural effects of naltrexone on food reward and aversion: implications for the treatment of obesity.Psychopharmacology · 2014Trial
- Naltrexone treatment for opioid dependence: does its effectiveness depend on testing the blockade?Drug and alcohol dependence · 2013Trial
- Effects of amphetamine on the human brain opioid system--a positron emission tomography study.The international journal of neuropsychopharmacology · 2013Trial
- Exploratory study of associations between monetary reward anticipation brain responses and mu-opioid signalling in alcohol dependence, gambling disorder and healthy controls.Neuroimage. Reports · 2024Article
- Opioidergic tuning of social attachment: reciprocal relationship between social deprivation and opioid abuse.Frontiers in neuroanatomy · 2024Review
- Tramadol Treatment Induces Change in Phospho-Cyclic Adenosine Monophosphate Response Element-Binding Protein and Delta and Mu Opioid Receptors within Hippocampus and Amygdala Areas of Rat Brain.Addiction & health · 2021Article
- The role of the opioid system in decision making and cognitive control: A review.Cognitive, affective & behavioral neuroscience · 2019Review
- Increased cocaine reward in offspring of females exposed to morphine during adolescence.Psychopharmacology · 2019Article
- Effects of chronic fentanyl administration on behavioral characteristics of mice.Neuropsychopharmacology reports · 2019Article
- Is There a Role for GPCR Agonist Radiotracers in PET Neuroimaging?Frontiers in molecular neuroscience · 2019Review
- The role of neuronal nitric oxide synthase in cocaine place preference and mu opioid receptor expression in the nucleus accumbens.Psychopharmacology · 2018Article
- Toward biomarkers of the addicted human brain: Using neuroimaging to predict relapse and sustained abstinence in substance use disorder.Progress in neuro-psychopharmacology & biological psychiatry · 2018Review
- Opioid Modulation of Value-Based Decision-Making in Healthy Humans.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- Naltrexone modulates dopamine release following chronic, but not acute amphetamine administration: a translational study.Translational psychiatry · 2017Article
- Methamphetamine potentiates HIV-1 gp120-mediated autophagy via Beclin-1 and Atg5/7 as a pro-survival response in astrocytes.Cell death & disease · 2016Article
- Blunted Endogenous Opioid Release Following an Oral Amphetamine Challenge in Pathological Gamblers.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Prefrontal Cortical Opioids and Dysregulated Motivation: A Network Hypothesis.Trends in neurosciences · 2016Review
- Functional consequences of cocaine expectation: findings in a non-human primate model of cocaine self-administration.Addiction biology · 2016Article
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10 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundCocaine users not seeking treatment have increased regional brain mu-opioid receptor (mOR) binding that correlates with cocaine craving and tendency to relapse. In cocaine-abusing outpatients in treatment, the relationship of mOR binding and treatment outcome is unknown.
methodsWe determined whether regional brain mOR binding before treatment correlates with outcome and compared it with standard clinical predictors of outcome. Twenty-five individuals seeking outpatient treatment for cocaine abuse or dependence (DSM-IV) received up to 12 weeks of cognitive-behavioral therapy and cocaine abstinence reinforcement, whereby each cocaine-free urine was reinforced with vouchers redeemable for goods. Regional brain mOR binding was measured before treatment using positron emission tomography with [¹¹C]]-carfentanil (a selective mOR agonist). Main outcome measures were: 1) overall percentage of urines positive for cocaine during first month of treatment; and 2) longest duration (weeks) of abstinence from cocaine during treatment, all verified by urine toxicology.
resultsElevated mOR binding in the medial frontal and middle frontal gyri before treatment correlated with greater cocaine use during treatment. Elevated mOR binding in the anterior cingulate, medial frontal, middle frontal, middle temporal, and sublobar insular gyri correlated with shorter duration of cocaine abstinence during treatment. Regional mOR binding contributed significant predictive power for treatment outcome beyond that of standard clinical variables such as baseline drug and alcohol use.
conclusionsElevated mOR binding in brain regions associated with reward sensitivity is a significant independent predictor of treatment outcome in cocaine-abusing outpatients, suggesting a key role for the brain endogenous opioid system in cocaine addiction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.