Trial reportJournal of pain and symptom management2010
An exploratory study on the effects of an expectancy manipulation on chemotherapy-related nausea.
Trial report in Journal of pain and symptom management, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00243269 (Acupressure and Relaxation for Nausea Control), which is not on this map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Acupressure and Relaxation for Nausea Control
Who cites it
18 citing papers in PubMed, 40 citations in OpenAlex.
- Positive effects of acupressure bands combined with relaxation music/instructions on patients most at risk for chemotherapy-induced nausea.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019Trial
- Trial
- The efficiency of the acupressure in prevention of the chemotherapy-induced nausea and vomiting.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2013Trial
- Understanding Placebo and Nocebo Responses Based on a Randomized Sham-Controlled Study on Acupuncture in Integrative Cancer Care.Integrative cancer therapiesTrial
- Article
- Optimizing Expectations About Endocrine Treatment for Breast Cancer: Results of the Randomized Controlled PSY-BREAST Trial.Clinical psychology in Europe · 2020Article
- Placebo and Nocebo Effects Across Symptoms: From Pain to Fatigue, Dyspnea, Nausea, and Itch.Frontiers in psychiatry · 2019Review
- Individual Factors Contributing to Nausea in First-Time Chemotherapy Patients: A Prospective Cohort Study.Frontiers in pharmacology · 2019Article
- Influencing Side-Effects to Medicinal Treatments: A Systematic Review of Brief Psychological Interventions.Frontiers in psychiatry · 2018Article
- Controlling chemotherapy-induced nausea requires further improvement: symptom experience and risk factors among Korean patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2016Article
- An investigation of the effects of therapeutic touch plan on acute chemotherapy-induced nausea in women with breast cancer in Isfahan, Iran, 2012-2013.Journal of education and health promotion · 2015Article
- Anticipatory nausea and vomiting due to chemotherapy.European journal of pharmacology · 2014Review
- Individual differences in chemotherapy-induced anticipatory nausea.Frontiers in psychology · 2013Article
- The nocebo effect and its relevance for clinical practice.Psychosomatic medicine · 2011Review
- Treatment of Nausea and Vomiting During Chemotherapy.US oncology & hematology · 2011Article
- Chemotherapy-induced Emesis: Experienced Burden in Life, and Significance of Treatment Expectations and Communication in Chemotherapy Care.Integrative cancer therapiesArticle
- A Basis for Strengthening Coping Strategies and Treatment Expectations in Patients Undergoing Emetogenic Pelvic-Abdominal Radiotherapy: A Longitudinal Study.Integrative cancer therapiesArticle
- The Significance of Communication and Treatment Expectations in Cancer Care: An Interview Study With Cancer Care Practitioners.Integrative cancer therapiesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
contextPrevious research has shown that the effectiveness of acupressure bands in reducing chemotherapy-related nausea is related to patients' expectations of efficacy.
objectiveTo test whether an informational manipulation designed to increase expectation of efficacy regarding acupressure bands would enhance their effectiveness.
methodsWe conducted an exploratory, four-arm, randomized clinical trial in breast cancer patients about to begin chemotherapy. All patients received acupressure bands and a relaxation CD. This report focuses on Arm 1(expectancy-neutral informational handout and CD) compared with Arm 4 (expectancy-enhancing handout and CD). Randomization was stratified according to the patient's level of certainty that she would have treatment-induced nausea (two levels: high and low). Experience of nausea and use of antiemetics were assessed with a five-day diary.
resultsOur expectancy-enhancing manipulation resulted in improved control of nausea in the 26 patients with high nausea expectancies but lessened control of nausea in 27 patients having low nausea expectancies. This interaction effect (between expected nausea and intervention effectiveness) approached statistical significance for our analysis of average nausea (P=0.084) and reached statistical significance for our analysis of peak nausea (P=0.030). Patients receiving the expectancy-enhancing manipulation took fewer antiemetic pills outside the clinic (mean(enhanced)=12.6; mean(neutral)=18.5, P=0.003).
conclusionThis exploratory intervention reduced antiemetic use overall and also reduced nausea in patients who had high levels of expected nausea. Interestingly, it increased nausea in patients who had low expectancies for nausea. Confirmatory research is warranted.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.