Trial reportThe Journal of allergy and clinical immunology2010
Indoor pet exposure and the outcomes of total IgE and sensitization at age 18 years.
Trial report in The Journal of allergy and clinical immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 43 citations in OpenAlex.
- Effect of prenatal indoor pet exposure on the trajectory of total IgE levels in early childhood.The Journal of allergy and clinical immunology · 2011Trial
- Indoor Environmental Exposures and Their Relationship to Allergic Diseases.The journal of allergy and clinical immunology. In practice · 2023Article
- Allergen Management in Children with Type 2-High Asthma.Journal of asthma and allergy · 2022Review
- Inner-City Asthma in Children.Clinical reviews in allergy & immunology · 2019Review
- Birth Mode, Breastfeeding, Pet Exposure, and Antibiotic Use: Associations With the Gut Microbiome and Sensitization in Children.Current allergy and asthma reports · 2019Review
- Dog introduction alters the home dust microbiota.Indoor air · 2018Article
- Lactobacillus johnsonii supplementation attenuates respiratory viral infection via metabolic reprogramming and immune cell modulation.Mucosal immunology · 2017Article
- Subgroup differences in the associations between dog exposure during the first year of life and early life allergic outcomes.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2017Article
- Recent Understandings of Pet Allergies.F1000Research · 2016Review
- Allergies and Asthma: Do Atopic Disorders Result from Inadequate Immune Homeostasis arising from Infant Gut Dysbiosis?Expert review of clinical immunology · 2016Article
- Objective assessment of persistent rhinitis in Chinese and its relationship with serum indicators.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2015Article
- Prevalence of allergic sensitization in the United States: results from the National Health and Nutrition Examination Survey (NHANES) 2005-2006.The Journal of allergy and clinical immunology · 2014Article
- The indoor environment and inner-city childhood asthma.Asian Pacific journal of allergy and immunology · 2014Review
- Relationship between childhood body mass index and young adult asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2012Article
- A new model for environmental assessment and exposure reduction.Current allergy and asthma reports · 2012Review
- Microbial regulation of allergic responses to food.Seminars in immunopathology · 2012Review
- Both the variability and level of mouse allergen exposure influence the phenotype of the immune response in workers at a mouse facility.The Journal of allergy and clinical immunology · 2011Article
- Lifetime dog and cat exposure and dog- and cat-specific sensitization at age 18 years.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2011Article
- Pediatric asthma: natural history, assessment, and treatment.The Mount Sinai journal of medicine, New YorkReview
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundEarly-life exposure to household pets has been shown to be protective against allergic sensitization in childhood.
objectiveWe sought to evaluate the association between early-life pet exposure and allergic sensitization at age 18 years.
methodsTeenagers who had been enrolled in the Detroit Childhood Allergy Study birth cohort in 1987-1989 were contacted at age 18 years. Serum total and allergen-specific IgE levels to 7 common allergens (dust mite, cat, dog, ragweed, Timothy grass, Alternaria species, and peanut; atopy was defined as any specific IgE level > or =0.35 kU/L) were measured at age 18 years. Annual interview data from childhood were used to determine indoor dog and cat (> or =50% of their time in the home) exposure during early life. Exposure was considered in various ways: first year, cumulative lifetime, and age groups, as well as multiple pets.
resultsDog or cat exposure in the first year of life was not associated with atopy (relative risk, 0.97; 95% CI, 0.83-1.12). Those living with pets in the first year and atopic at 18 years had lower total IgE levels. Neither cumulative exposure nor exposure at a particular age was strongly and consistently associated with either outcome. Although not statistically significant, there was a pattern of decreased odds of sensitization among those with 2 or more pets versus no pets in the first year of life.
conclusionsEarly-life pet exposure can be associated with lower total IgE levels among atopic subjects but is not strongly associated with decreased likelihood of sensitization to common allergens at age 18 years.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.