ArticleComparative medicine2010
Cellular compensatory mechanisms in the CNS of dysmyelinated rats.
Article in Comparative medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Article
- Cortical amyloid-beta burden is associated with changes in intracortical myelin in cognitively normal older adults.Translational psychiatry · 2023Article
- Effects of non-modifiable risk factors of Alzheimer's disease on intracortical myelin content.Alzheimer's research & therapy · 2022Article
- The Role of Astrogliosis in Formation of the Syrinx in Spinal Cord Injury.Current neuropharmacology · 2021Review
- The Pathogenesis of Neurotrauma Indicates Targets for Neuroprotective Therapies.Current neuropharmacology · 2021Article
- Article
- Myelination of Purkinje axons is critical for resilient synaptic transmission in the deep cerebellar nucleus.Scientific reports · 2018Article
- Myelination is delayed during postnatal brain development in the mdx mouse model of Duchenne muscular dystrophy.BMC neuroscience · 2017Article
- Central dysmyelination reduces the temporal fidelity of synaptic transmission and the reliability of postsynaptic firing during high-frequency stimulation.Journal of neurophysiology · 2013Article
- Endpoints in myelin-deficient (MD) rats.Comparative medicine · 2010Article
- Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Loss or absolute lack of myelin in the CNS results in remarkable compensation at the cellular level. In this study on the natural progression of neuropathology in the CNS in 2 related but distinct long-lived dysmyelinated rats, total lack of myelin was associated with remarkable glial cell proliferation and ineffective myelinating activity throughout life in Long Evans Bouncer (LE-bo) rats; conversely, in Long Evans Shaker (LES) rats, futile myelinating activity ceased when rats were advanced in age. Progressively severe astrogliosis separates individual axons from each other and coincides with widespread, abundant axonal sprouting throughout the life in both rat strains. Severely dysmyelinated Long Evans rats can serve as excellent models to elucidate the cellular and molecular mechanisms of neuroglial compensation to lack or loss of myelin in vivo and to study axonal plasticity in the adult demyelinated CNS.
Indexed as
Identifiers
20579436PMC2890396W1746221723What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.