ArticleMagnetic resonance in medicine2010
1H MRS of intramyocellular lipids in soleus muscle at 7 T: spectral simplification by using long echo times without water suppression.
Article in Magnetic resonance in medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 44 citations in OpenAlex.
- Brain and muscle chemistry in myalgic encephalitis/chronic fatigue syndrome (ME/CFS) and long COVID: a 7T magnetic resonance spectroscopy study.Molecular psychiatry · 2025Article
- Sex Differences in Fat Distribution and Muscle Fat Infiltration in the Lower Extremity: A Retrospective Diverse-Ethnicity 7T MRI Study in a Research Institute Setting in the USA.Diagnostics (Basel, Switzerland) · 2024Article
- Proton magnetic resonance spectroscopy in skeletal muscle: Experts' consensus recommendations.NMR in biomedicine · 2021Review
- Spectroscopic sampling of the left side of long-TE spin echoes: a free lunch?Magma (New York, N.Y.) · 2018Article
- Compositional marker in vivo reveals intramyocellular lipid turnover during fasting-induced lipolysis.Scientific reports · 2018Article
- The influence of leg positioning on the appearance and quantification ofPolish journal of radiology · 2018Article
- Differences in Muscle Metabolism Between Triathletes and Normally Active Volunteers Investigated Using Multinuclear Magnetic Resonance Spectroscopy at 7T.Frontiers in physiology · 2018Article
- Intramyocellular lipid excess in the mitochondrial disorder MELAS: MRS determination at 7T.Neurology. Genetics · 2017Article
- Correlated spectroscopic imaging of calf muscle in three spatial dimensions using group sparse reconstruction of undersampled single and multichannel data.Magnetic resonance in medicine · 2015Article
- Fiber orientation measurements by diffusion tensor imaging improve hydrogen-1 magnetic resonance spectroscopy of intramyocellular lipids in human leg muscles.Journal of medical imaging (Bellingham, Wash.) · 2015Article
- Long-echo time MR spectroscopy for skeletal muscle acetylcarnitine detection.The Journal of clinical investigation · 2014Article
- Proton magnetic resonance spectroscopy of skeletal muscle: a comparison of two quantitation techniques.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2014Article
- Quantitative proton MR techniques for measuring fat.NMR in biomedicine · 2013Review
- Article
- Dynamic monitoring of carnitine and acetylcarnitine in the trimethylamine signal after exercise in human skeletal muscle by 7T 1H-MRS.Magnetic resonance in medicine · 2013Article
- Intramyocellular lipids versus intramyocellular triglycerides.Magnetic resonance in medicine · 2012Article
- Applications of multi-nuclear magnetic resonance spectroscopy at 7T.World journal of radiology · 2011Article
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3 authors at 3 institutions in 1 country.
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Abstract
The popular short echo time (1)H MR spectroscopy acquisition method for detection of intramyocellular lipids suffers from spectral overlap due to the large, broad, and asymmetric extramyocellular lipid signals, the time-consuming practice of selecting "lean" voxels for spectroscopy, and the overlap of the extramyocellular lipid signal with the creatine methyl (1)H signal at approximately 3 parts per million (ppm), commonly used as an internal standard. Using an alternative acquisition strategy, spectra with well-resolved intramyocellular lipids resonances were acquired from large volumes (10 to 15 mL) of human soleus muscle in less than 5 min by single-voxel 7-T (1)H MR spectroscopy, using an echo time of 280 ms. From the high-resolution spectra, an average intramyocellular lipid concentration of 7.7 +/- 3.5 mmol/kg muscle was found for 25 healthy subjects (male/female 17/8; age 29.4 +/- 6.6 years). Since water suppression was not required, the (1)H signals from unsaturated intracellular triglycerides at about 5.3 ppm were easily detected, which, in combination with the well-determined -(CH(2))(n)-/CH(3) intensity ratio at long echo time, enabled assessment of the composition of triglycerides in the intramyocellular lipids compartment. Long-echo single-voxel spectroscopy at 7 T offers rapid and convenient acquisition of high-resolution spectra from human soleus muscle.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.