Evidence map›Paper›PMID 20578001›Full record

ReviewBiopolymers2010

Recent advancements in the biosynthetic mechanisms for polyketide-derived mycotoxins.

Justin Huffman, Ryan Gerber, Liangcheng Du

Open access · bronzeAbstract readReview
In one paragraph

Review in Biopolymers, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
9.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 164 citations in OpenAlex.

  1. Review
  2. An endosymbiotic origin of the crimson pigment from the lac insect.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
  4. Unveiling toxigenicFrontiers in plant science · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Exposure Assessment of Aflatoxin B1 through Consumption of Rice in the United Arab Emirates.International journal of environmental research and public health · 2022
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Fungal Melanin and the Mammalian Immune System.Journal of fungi (Basel, Switzerland) · 2021
    Review
  18. Review
  19. Functional Role ofToxins · 2021
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Justin HuffmanDepartment of Chemistry, University of Nebraska-Lincoln, NE 68588, USA.
Ryan Gerber
Liangcheng Du
University of Nebraska–Lincoln · US

Funding

EXTRAMURAL RESEARCH FACILITIES CONSTRUCTIONC06RR015468 · NCRR · UNIVERSITY OF NEBRASKA LINCOLN · PI PAUL, PREM S · 2000 to 2000
$2.0M
Biosynthesis of HSAF, an antifungal natural product with a novel mode of actionR03AI073510 · NIAID · UNIVERSITY OF NEBRASKA LINCOLN · PI DU, LIANGCHENG · 2008 to 2009
$191k
NCRR NIH HHS C06 RR015468NCRR NIH HHS RR015468-01NIAID NIH HHS AI073510NIAID NIH HHS R03 AI073510
6 · The paper itself

Abstract

Polyketides (PKs) are a large group of natural products produced by microorganisms and plants. They are biopolymers of acetate and other short carboxylates and are biosynthesized by multifunctional enzymes called polyketide synthases (PKSs). This review discusses the biosynthesis of four toxic PK, aflatoxins, fumonisins, ochratoxins (OTs), and zearalenone. These metabolites are structurally diverse and differ in their mechanisms of toxicity. However, they are all of concern in food safety and agriculture because of their toxic properties and their frequent accumulation in crops used for food and feed. The focus is on the recent advancements in the understanding of the molecular mechanisms for the biosynthesis of these mycotoxins. Several of the mycotoxin PKSs have been genetically and biochemically studied while other PKSs remain to be investigated. Multiple post-PKS modifications are often required for the maturation of the mycotoxins. Many of these modification steps for aflatoxins and fumonisins are well established while the post-PKS modifications for zearalenone and OTs remain to be biochemically characterized. More efforts are needed to completely illustrate the biosynthetic mechanisms for this important group of PKs.

Indexed as

Food ContaminationMacrolidesMitosporic FungiMycotoxinsMacrolidesMycotoxins

Identifiers

PMID20578001
PMCPMC2894268
OpenAlexW2049795722

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.