ReviewHeart failure reviews2011
Methods of assessing vagus nerve activity and reflexes.
Review in Heart failure reviews, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
80 citing papers in PubMed, 1 synthesis or guideline pooled it, 178 citations in OpenAlex.
- Heart rate variability in relation to cognition and behavior in neurodegenerative diseases: A systematic review and meta-analysis.Ageing research reviews · 2022Pooled it
- Acute cocoa ingestion decreases spontaneous cardiac baroreflex sensitivity in healthy older adults.American journal of physiology. Regulatory, integrative and comparative physiology · 2026Trial
- Daily biofeedback to modulate heart rate oscillations affects structural volume in hippocampal subregions targeted by the locus coeruleus in older adults but not younger adults.Neurobiology of aging · 2023Trial
- Trial
- Do pigs have altruistic behaviour based on cognitive empathy?BMC veterinary research · 2026Article
- Interpreting heart rate variability in clinical context: a framework for understanding a multidimensional autonomic biomarker.Frontiers in cardiovascular medicine · 2026Review
- Effects of different light spectra on locomotion, anxiety, and heart rate in spontaneously hypertensive rats and Wistar-Kyoto rats.IBRO neuroscience reports · 2025Article
- Heart Rate Profiles During Exercise and Incident Parkinson's Disease.Annals of neurology · 2025Article
- Ambulatory physiological measures obtained under naturalistic urban mobility conditions have acceptable reliability.Scientific reports · 2025Article
- The effects of limb suction during arterial occlusion on arterial baroreflex in humans.American journal of physiology. Heart and circulatory physiology · 2025Article
- Autonomic dysfunction in neurodegenerative disease.Nature reviews. Neuroscience · 2025Review
- Effect of Anesthesia and Diurnal Variation on Chronic Vagus Nerve Activity in Rats.Journal of neuroscience research · 2025Article
- Noninvasive assessment of temporal dynamics in sympathetic and parasympathetic baroreflex responses.Physiological measurement · 2025Article
- Evaluation of In-Ear and Fingertip-Based Photoplethysmography Sensors for Measuring Cardiac Vagal Tone Relevant Heart Rate Variability Parameters.Sensors (Basel, Switzerland) · 2025Article
- Application of transcutaneous electrical nerve stimulation in monitored anesthesia care during foraminoscopy: a randomized double-blind controlled trial.Frontiers in medicine · 2025Article
- Inter- and intra-examiner reliability of short-term measurement of heart rate variability on rest in patients hospitalized with COVID-19.Scientific reports · 2024Article
- Noninvasive Assessment of Temporal Dynamics in Sympathetic and Parasympathetic Baroreflex Responses.bioRxiv : the preprint server for biology · 2024Article
- Highly-stable, injectable, conductive hydrogel for chronic neuromodulation.Nature communications · 2024Article
- More efficient adaptation of cardiovascular response to repeated restraint in spontaneously hypertensive rats: the role of autonomic nervous system.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Impact of Obstructive Sleep Apnea and Sympathetic Nervous System on Cardiac Health: A Comprehensive Review.Journal of cardiovascular development and disease · 2024Review
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The methods used to assess cardiac parasympathetic (cardiovagal) activity and its effects on the heart in both humans and animal models are reviewed. Heart rate (HR)-based methods include measurements of the HR response to blockade of muscarinic cholinergic receptors (parasympathetic tone), beat-to-beat HR variability (HRV) (parasympathetic modulation), rate of post-exercise HR recovery (parasympathetic reactivation), and reflex-mediated changes in HR evoked by activation or inhibition of sensory (afferent) nerves. Sources of excitatory afferent input that increase cardiovagal activity and decrease HR include baroreceptors, chemoreceptors, trigeminal receptors, and subsets of cardiopulmonary receptors with vagal afferents. Sources of inhibitory afferent input include pulmonary stretch receptors with vagal afferents and subsets of visceral and somatic receptors with spinal afferents. The different methods used to assess cardiovagal control of the heart engage different mechanisms, and therefore provide unique and complementary insights into underlying physiology and pathophysiology. In addition, techniques for direct recording of cardiovagal nerve activity in animals; the use of decerebrate and in vitro preparations that avoid confounding effects of anesthesia; cardiovagal control of cardiac conduction, contractility, and refractoriness; and noncholinergic mechanisms are described. Advantages and limitations of the various methods are addressed, and future directions are proposed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.