ArticleFrontiers in aging neuroscience2010
Cross-talk between mitochondria and proteasome in Parkinson's disease pathogenesis.
Article in Frontiers in aging neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- The possible involvement of mitochondrial dysfunctions in Lewy body dementia: a systematic review.Functional neurologyPooled it
- Impaired Mitochondrial Function and Ubiquitin Proteasome System Activate α-Synuclein Aggregation in Zinc-Induced Neurotoxicity: Effect of Antioxidants.Journal of molecular neuroscience : MN · 2025Article
- Aggregation-Inhibiting scFv-Based Therapies Protect Mice against AAV1/2-Induced A53T-α-Synuclein Overexpression.Biomolecules · 2023Article
- SARS-CoV-2 and other coronaviruses negatively influence mitochondrial quality control: beneficial effects of melatonin.Pharmacology & therapeutics · 2021Review
- Neurotoxicity of pesticides.Acta neuropathologica · 2019Review
- Dexamethasone Inhibits Copper-Induced Alpha-Synuclein Aggregation by a Metallothionein-Dependent Mechanism.Neurotoxicity research · 2018Article
- Metallothionein, Copper and Alpha-Synuclein in Alpha-Synucleinopathies.Frontiers in neuroscience · 2017Review
- MicroRNA-mRNA regulatory networking fine-tunes the porcine muscle fiber type, muscular mitochondrial respiratory and metabolic enzyme activities.BMC genomics · 2016Article
- The ubiquitin-conjugating enzyme UBE2E3 and its import receptor importin-11 regulate the localization and activity of the antioxidant transcription factor NRF2.Molecular biology of the cell · 2015Article
- Ubiquitin proteasome system in Parkinson's disease: a keeper or a witness?Experimental neurology · 2012Article
- Dopaminochrome induces caspase-independent apoptosis in the mesencephalic cell line, MN9D.Journal of neurochemistry · 2012Article
- The emerging role of proteolysis in mitochondrial quality control and the etiology of Parkinson's disease.Parkinson's disease · 2012Article
- Mitochondrial dysfunction in Parkinson's disease.Parkinson's disease · 2011Article
- Lipid-mediated oxidative stress and inflammation in the pathogenesis of Parkinson's disease.Parkinson's disease · 2011Article
- The endotoxin-induced neuroinflammation model of Parkinson's disease.Parkinson's disease · 2011Article
- Idebenone and resveratrol extend lifespan and improve motor function of HtrA2 knockout mice.PloS one · 2011Article
- Protein aggregation containing β-amyloid, α-synuclein and hyperphosphorylated τ in cultured cells of hippocampus, substantia nigra and locus coeruleus after rotenone exposure.BMC neuroscience · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parkinson's disease (PD) is the most common progressive neurodegenerative movement disorder, characterized by the selective loss of nigrostriatal dopaminergic neurons, and the presence of intracellular insoluble proteinaceous inclusions, known as Lewy Bodies. Although PD etiopathogenesis remains elusive, the leading hypothesis for the death of specific groups of neurons establishes that mitochondrial dysfunction, alterations in the ubiquitin-proteasomal system (UPS), and oxidative stress are major events that act synergistically causing this devastating disease. In this review we will focus on mitochondrial impairment and its implications on proteasomal function and alpha-synuclein aggregation. We will address the role of mitochondria and proteasome cross-talk in the neuronal loss that leads to PD and discuss how this knowledge might further improve patient therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.