ArticleFrontiers in neuroenergetics2010
Spatial Relationship between Flavoprotein Fluorescence and the Hemodynamic Response in the Primary Visual Cortex of Alert Macaque Monkeys.
Article in Frontiers in neuroenergetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Spatiotemporal relationships between neuronal, metabolic, and hemodynamic signals in the awake and anesthetized mouse brain.Cell reports · 2024Article
- Mapping cortical mesoscopic networks of single spiking cortical or sub-cortical neurons.eLife · 2017Article
- Imaging of Neuronal Activity in Awake Mice by Measurements of Flavoprotein Autofluorescence Corrected for Cerebral Blood Flow.Frontiers in neuroscience · 2017Article
- Wide-field optical mapping of neural activity and brain haemodynamics: considerations and novel approaches.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Rapid Postnatal Expansion of Neural Networks Occurs in an Environment of Altered Neurovascular and Neurometabolic Coupling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Mesoscale transcranial spontaneous activity mapping in GCaMP3 transgenic mice reveals extensive reciprocal connections between areas of somatomotor cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Surround suppression maps in the cat primary visual cortex.Frontiers in neural circuits · 2013Article
- Frontiers in optical imaging of cerebral blood flow and metabolism.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2012Review
- Evolution of the dynamic changes in functional cerebral oxidative metabolism from tissue mitochondria to blood oxygen.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2012Article
- Neurovascular imaging.Frontiers in neuroenergetics · 2012Article
- Preictal and ictal neurovascular and metabolic coupling surrounding a seizure focus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Cellular and metabolic origins of flavoprotein autofluorescence in the cerebellar cortex in vivo.Cerebellum (London, England) · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Flavoprotein fluorescence imaging (FFI) is a novel intrinsic optical signal that is steadily gaining ground as a valuable imaging tool in neuroscience research due to its closer relationship with local metabolism relative to the more commonly used hemodynamic signals. We have developed a technique for FFI imaging in the primary visual cortex (V1) of alert monkeys. Due to the nature of neurovascular coupling, hemodynamic signals are known to spread beyond the locus of metabolic activity. To determine whether FFI signals could provide a more focal measure of cortical activity in alert animals, we compared FFI and hemodynamic point spreads (i.e. responses to a minimal visual stimulus) and functional mapping signals over V1 in macaques performing simple fixation tasks. FFI responses were biphasic, with an early and focal fluorescence increase followed by a delayed and spatially broader fluorescence decrease. As expected, the early fluorescence increase, indicating increased local oxidative metabolism, was somewhat narrower than the simultaneously observed hemodynamic response. However, the later FFI decrease was broader than the hemodynamic response and started prior to the cessation of visual stimulation suggesting different mechanisms underlying the two phases of the fluorescence signal. FFI mapping signals were free of vascular artifacts and comparable in amplitude to hemodynamic mapping signals. These results indicate that the FFI response may be a more local and direct indicator of cortical metabolism than the hemodynamic response in alert animals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.