ArticleFrontiers in behavioral neuroscience2010
Optogenetically Induced Olfactory Stimulation in Drosophila Larvae Reveals the Neuronal Basis of Odor-Aversion behavior.
Article in Frontiers in behavioral neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 75 citations in OpenAlex.
- Entirely synthetic memory inception via dual optogenetic activation of sensory and dopaminergic neurons.iScience · 2025Article
- Receptors underlying an odorant's valence across concentrations in Drosophila larvae.The Journal of experimental biology · 2024Article
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- Circuit analysis of theNetwork neuroscience (Cambridge, Mass.) · 2023Article
- Optogenetic and thermogenetic manipulation of defined neural circuits and behaviors inLearning & memory (Cold Spring Harbor, N.Y.) · 2022Article
- Article
- Optogenetic Techniques for Manipulating and Sensing G Protein-Coupled Receptor Signaling.Methods in molecular biology (Clifton, N.J.) · 2020Review
- Stochastic and Arbitrarily Generated Input Patterns to the Mushroom Bodies Can Serve as Conditioned Stimuli inFrontiers in physiology · 2020Article
- Prior activity of olfactory receptor neurons is required for proper sensory processing and behavior in Drosophila larvae.Scientific reports · 2018Article
- Aversive and Appetitive Learning inJournal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience · 2018Article
- Insect-controlled Robot: A Mobile Robot Platform to Evaluate the Odor-tracking Capability of an Insect.Journal of visualized experiments : JoVE · 2016Article
- Article
- The whole genome sequence of the Mediterranean fruit fly, Ceratitis capitata (Wiedemann), reveals insights into the biology and adaptive evolution of a highly invasive pest species.Genome biology · 2016Article
- Olfactory Mechanisms for Discovery of Odorants to Reduce Insect-Host Contact.Journal of chemical ecology · 2016Review
- Behavior Reveals Selective Summation and Max Pooling among Olfactory Processing Channels.Neuron · 2016Article
- Article
- Short-term memory trace mediated by termination kinetics of olfactory receptor.Scientific reports · 2016Article
- Genome-Wide Comparative Analysis of Chemosensory Gene Families in Five Tsetse Fly Species.PLoS neglected tropical diseases · 2016Article
- A Single Pair of Serotonergic Neurons Counteracts Serotonergic Inhibition of Ethanol Attraction in Drosophila.PloS one · 2016Article
- Artificial Induction of Associative Olfactory Memory by Optogenetic and Thermogenetic Activation of Olfactory Sensory Neurons and Octopaminergic Neurons in Drosophila Larvae.Frontiers in behavioral neuroscience · 2016Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Olfactory stimulation induces an odor-guided crawling behavior of Drosophila melanogaster larvae characterized by either an attractive or a repellent reaction. In order to understand the underlying processes leading to these orientations we stimulated single olfactory receptor neurons (ORNs) through photo-activation within an intact neuronal network. Using the Gal4-UAS system two light inducible proteins, the light-sensitive cation channel channelrhodopsin-2 (ChR-2) or the light-sensitive adenylyl cyclase (Pacalpha) were expressed in all or in individual ORNs of the larval olfactory system. Blue light stimulation caused an activation of these neurons, ultimately producing the illusion of an odor stimulus. Larvae were tested in a phototaxis assay for their orientation toward or away from the light source. Here we show that activation of Pacalpha expressing ORNs bearing the receptors Or33b or Or45a in blind norpA mutant larvae induces a repellent behavior away from the light. Conversely, photo-activation of the majority of ORNs induces attraction towards the light. Interestingly, in wild type larvae two ligands of Or33b and Or45a, octyl acetate and propionic ethylester, respectively, have been found to cause an escape reaction. Therefore, we combined light and odor stimulation to analyze the function of Or33b and Or45a expressing ORNs. We show that the larval olfactory system contains a designated neuronal pathway for repellent odorants and that activation of a specific class of ORNs already determines olfactory avoidance behavior.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.