ArticlePsychiatry investigation2010
Apolipoprotein e4 genotype and depressive symptoms as risk factors for dementia in an older korean population.
Article in Psychiatry investigation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Depressive Symptoms in the Elderly-An Early Symptom of Dementia? A Systematic Review.Frontiers in pharmacology · 2020Pooled it
- Dementia risk estimates associated with measures of depression: a systematic review and meta-analysis.BMJ open · 2015Pooled it
- Late-life depression and risk of vascular dementia and Alzheimer's disease: systematic review and meta-analysis of community-based cohort studies.The British journal of psychiatry : the journal of mental science · 2013Pooled it
- Incidence and Cognitive Decline of Alzheimer's Disease and Other Dementia by Apolipoprotein ε4 Allele Presence: A Community-Based Cohort Study in Korean Elderly.Psychiatry investigation · 2022Article
- Depression as a Risk Factor for Alzheimer's Disease: A Systematic Review of Longitudinal Meta-Analyses.Journal of clinical medicine · 2021Review
- Aberrant Default Mode Network Underlying the Cognitive Deficits in the Patients With Late-Onset Depression.Frontiers in aging neuroscience · 2018Review
- Apolipoprotein E ε4 genotype and the temporal relationship between depression and dementia.Neurobiology of aging · 2015Article
- Interactions between the apolipoprotein E ε4 allele status and adverse childhood experiences on depressive symptoms in older adults.European journal of psychotraumatology · 2015Article
- The potential applications of Apolipoprotein E in personalized medicine.Frontiers in aging neuroscience · 2014Review
- Aberrant apolipoprotein E expression and cognitive dysfunction in patients with poststroke depression.Genetic testing and molecular biomarkers · 2013Article
- Apolipoprotein E epsilon 4 allele and outcomes of traumatic spinal cord injury in a Chinese Han population.Molecular biology reports · 2011Article
- Neuropsychiatric Symptoms, Endophenotypes, and Syndromes in Late-Onset Alzheimer's Disease: Focus on APOE Gene.International journal of Alzheimer's disease · 2011Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveGrowing evidence suggests the separate associations of apolipoprotein E e4 allele (apo E4) and depression with incident dementia. This study investigated the separate and combined effects of apo E4 and depression on the incidence of dementia in both men and women.
methodsOf 625 elderly without dementia at baseline, 518 (83%) were followed over a 2.4-year period and were assessed clinically for incident dementia. The apo E polymorphism was ascertained, and depression was identified using the Korean version of the Geriatric Depression Scale (KGDS). Covariates included age, gender, education, disability, alcohol history, physical activity, and vascular risk factors.
resultsThe incidence of dementia was significantly higher in elderly Koreans with both apo E4 and depression compared to those without both factors [adjusted odds ratio (95% CI)=5.85 (1.77-19.38)]. This interaction was significant in men (p=0.049), but not in women (p=0.354).
conclusionDepressed elderly people are at great risk for incident dementia in the presence of apo E4. Potential gender differences require further evaluation.
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