ArticleFrontiers in cellular neuroscience2010
High-Pass Filtering and Dynamic Gain Regulation Enhance Vertical Bursts Transmission along the Mossy Fiber Pathway of Cerebellum.
Article in Frontiers in cellular neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40 citing papers in PubMed, 58 citations in OpenAlex.
- A computational model of the cerebellar granular layer calibrated to experimental data for studying inhibition and sensory encoding.Scientific reports · 2025Article
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- Enhanced electrophysiological recordings in acute brain slices, spheroids, and organoids using 3D high-density multielectrode arrays.PloS one · 2025Article
- Review
- Anisotropy and Frequency Dependence of Signal Propagation in the Cerebellar Circuit Revealed by High-Density Multielectrode Array Recordings.Biomedicines · 2023Article
- Long-Term Synaptic Plasticity Tunes the Gain of Information Channels through the Cerebellum Granular Layer.Biomedicines · 2022Article
- Model simulations unveil the structure-function-dynamics relationship of the cerebellar cortical microcircuit.Communications biology · 2022Article
- Discovering Microcircuit Secrets With Multi-Spot Imaging and Electrophysiological Recordings: The Example of Cerebellar Network Dynamics.Frontiers in cellular neuroscience · 2022Review
- The effects of the general anesthetic sevoflurane on neurotransmission: an experimental and computational study.Scientific reports · 2021Article
- Stellate cell computational modeling predicts signal filtering in the molecular layer circuit of cerebellum.Scientific reports · 2021Article
- Retina-Inspired Organic Heterojunction-Based Optoelectronic Synapses for Artificial Visual Systems.Research (Washington, D.C.) · 2021Article
- Granular layEr Simulator: Design and Multi-GPU Simulation of the Cerebellar Granular Layer.Frontiers in computational neuroscience · 2021Article
- Cellular-resolution mapping uncovers spatial adaptive filtering at the rat cerebellum input stage.Communications biology · 2020Article
- Diverse Neuron Properties and Complex Network Dynamics in the Cerebellar Cortical Inhibitory Circuit.Frontiers in molecular neuroscience · 2019Article
- Optogenetic stimulation of complex spatio-temporal activity patterns by acousto-optic light steering probes cerebellar granular layer integrative properties.Scientific reports · 2018Article
- Noise-enhanced coding in phasic neuron spike trains.PloS one · 2017Article
- A Hybrid Model for the Computationally-Efficient Simulation of the Cerebellar Granular Layer.Frontiers in computational neuroscience · 2016Article
- Tactile Stimulation Evokes Long-Lasting Potentiation of Purkinje Cell Discharge In Vivo.Frontiers in cellular neuroscience · 2016Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Signal elaboration in the cerebellum mossy fiber input pathway presents controversial aspects, especially concerning gain regulation and the spot-like (rather than beam-like) appearance of granular to molecular layer transmission. By using voltage-sensitive dye imaging in rat cerebellar slices (Mapelli et al., 2010), we found that mossy fiber bursts optimally excited the granular layer above approximately 50 Hz and the overlaying molecular layer above approximately 100 Hz, thus generating a cascade of high-pass filters. NMDA receptors enhanced transmission in the granular, while GABA-A receptors depressed transmission in both the granular and molecular layer. Burst transmission gain was controlled through a dynamic frequency-dependent involvement of these receptors. Moreover, while high-frequency transmission was enhanced along vertical lines connecting the granular to molecular layer, no high-frequency enhancement was observed along the parallel fiber axis in the molecular layer. This was probably due to the stronger effect of Purkinje cell GABA-A receptor-mediated inhibition occurring along the parallel fibers than along the granule cell axon ascending branch. The consequent amplification of burst responses along vertical transmission lines could explain the spot-like activation of Purkinje cells observed following punctuate stimulation in vivo.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.