ArticleTetrahedron letters2009
Microwave-assisted sequential one-pot protocol to benzothiadiazin-3-one-1,1-dioxides via a copper-catalyzed N-arylation strategy.
Article in Tetrahedron letters, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Facile synthesis of benzothiadiazine 1,1-dioxides, a precursor of RSV inhibitors, by tandem amidation/intramolecular aza-Wittig reaction.Beilstein journal of organic chemistry · 2013Article
- Exploring chemical diversity via a modular reaction pairing strategy.Beilstein journal of organic chemistry · 2012Article
- Synthesis of amino-benzothiaoxazepine-1,1-dioxides utilizing a microwave-assisted, S(N)Ar protocol.ACS combinatorial science · 2011Article
- Reagent based DOS: a "Click, Click, Cyclize" strategy to probe chemical space.Organic & biomolecular chemistry · 2010Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
A microwave-assisted, sequential, one-pot protocol has been developed for the synthesis of a variety of benzothiadiazin-3-one-1,1-dioxides. This protocol utilizes a copper-catalyzed N-arylation of α-bromo-benzenesulfonamides with a number of amines to generate the corresponding 2-aminobenzenesulfonamides, which undergo cyclization to the desired sultams using carbonyl diimidazole (CDI). A range of conditions was evaluated for the key C-N bond formation step with tolerance toward functionalized amines.
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Registered trials
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