ArticleShock (Augusta, Ga.)2011
Systemic inflammation and liver injury following hemorrhagic shock and peripheral tissue trauma involve functional TLR9 signaling on bone marrow-derived cells and parenchymal cells.
Article in Shock (Augusta, Ga.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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Who cites it
27 citing papers in PubMed, 39 citations in OpenAlex.
- Elevated levels of plasma mitochondrial DNA DAMPs are linked to clinical outcome in severely injured human subjects.Annals of surgery · 2013Trial
- Cationic microparticles inhibit local sterile inflammation in tissue injuries.Regenerative biomaterials · 2026Article
- Focal intra-colon cooling reduces organ injury and systemic inflammation after REBOA management of lethal hemorrhage in rats.Scientific reports · 2021Article
- A road map from single-cell transcriptome to patient classification for the immune response to trauma.JCI insight · 2021Article
- Potential Immune Indicators for Predicting the Prognosis of COVID-19 and Trauma: Similarities and Disparities.Frontiers in immunology · 2021Review
- Complement as a Major Inducer of Harmful Events in Infectious Sepsis.Shock (Augusta, Ga.) · 2020Review
- Macrophages play an essential role in trauma-induced sterile inflammation and tissue repair.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2018Review
- Scavenging Circulating Mitochondrial DNA as a Potential Therapeutic Option for Multiple Organ Dysfunction in Trauma Hemorrhage.Frontiers in immunology · 2018Observational
- Mouse Injury Model of Polytrauma and Shock.Methods in molecular biology (Clifton, N.J.) · 2018Review
- Characterization of hypoalbuminemia following temporary abdominal closure.The journal of trauma and acute care surgery · 2017Article
- NK1.1Journal of leukocyte biology · 2017Article
- Time for trauma immunology.PLoS medicine · 2017Article
- Tlr2 on Bone Marrow and Non-Bone Marrow Derived Cells Regulates Inflammation and Organ Injury in Cooperation with Tlr4 During Resuscitated Hemorrhagic Shock.Shock (Augusta, Ga.) · 2016Article
- Protective role of nuclear factor erythroid 2-related factor 2 in the hemorrhagic shock-induced inflammatory response.International journal of molecular medicine · 2016Article
- Article
- TLR2 Regulates Complement-Mediated Inflammation Induced by Blood Loss During Hemorrhage.Shock (Augusta, Ga.) · 2016Article
- Platelet-derived HMGB1 is a critical mediator of thrombosis.The Journal of clinical investigation · 2015Article
- Delayed neutralization of interleukin 6 reduces organ injury, selectively suppresses inflammatory mediator, and partially normalizes immune dysfunction following trauma and hemorrhagic shock.Shock (Augusta, Ga.) · 2014Article
- A better understanding of why murine models of trauma do not recapitulate the human syndrome.Critical care medicine · 2014Article
- Eritoran attenuates tissue damage and inflammation in hemorrhagic shock/trauma.The Journal of surgical research · 2013Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Hemorrhagic shock due to trauma (HS/T) induces an inflammatory response that can contribute to end-organ injury. The pathways involved in the initiation and propagation of HS/T-induced inflammation are incompletely understood. Here, we hypothesized that the DNA sensor TLR9 would have a role in inflammatory signaling after HS/T. Using mice expressing a nonfunctional, mutant form of TLR9, we identified a role of TLR9 in driving the initial cytokine response and liver damage in a model of hemorrhagic shock and bilateral femur fracture. Circulating DNA levels were found to correlate with the degree of tissue damage. Experiments using chimeric mice show that TLR9 on both bone marrow-derived cells and parenchymal cells are important for the TLR9-mediated liver and tissue damage, as well as systemic inflammation after HS/T. These data suggest that release of DNA may be a driver of the inflammatory response to severe injury as well as a marker of the extent of tissue damage. One of the sensors of DNA in the setting of HS/T seems to be TLR9.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.