ArticleJournal of acquired immune deficiency syndromes (1999)2010
Genetic variation of innate immune genes in HIV-infected african patients with or without oropharyngeal candidiasis.
Article in Journal of acquired immune deficiency syndromes (1999), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Association between dectin-1 gene single nucleotide polymorphisms and fungal infection: a systemic review and meta-analysis.Bioscience reports · 2019Pooled it
- The role of TLR4 896 A>G and 1196 C>T in susceptibility to infections: a review and meta-analysis of genetic association studies.PloS one · 2013Pooled it
- HIV, HPV, and oral health in Tanzania: a scoping review.Infectious agents and cancer · 2026Review
- Immunogenetics associated with severe coccidioidomycosis.JCI insight · 2022Article
- Review
- Dependence on Mincle and Dectin-2 Varies With MultipleFrontiers in microbiology · 2021Article
- Advances in Understanding Human Genetic Variations That Influence Innate Immunity to Fungi.Frontiers in cellular and infection microbiology · 2020Review
- The Interaction of Human Pathogenic Fungi With C-Type Lectin Receptors.Frontiers in immunology · 2018Review
- Medical mycology and fungal immunology: new research perspectives addressing a major world health challenge.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- The Kallikrein-Kinin System: A Novel Mediator of IL-17-Driven Anti-Candida Immunity in the Kidney.PLoS pathogens · 2016Article
- Polymorphisms of the immune-modulating receptor dectin-1 in pigs: their functional influence and distribution in pig populations.Immunogenetics · 2016Article
- Role of autophagy genetic variants for the risk of Candida infections.Medical mycology · 2014Article
- CASPASE-12 and rheumatoid arthritis in African-Americans.Immunogenetics · 2014Article
- Gene polymorphisms in pattern recognition receptors and susceptibility to idiopathic recurrent vulvovaginal candidiasis.Frontiers in microbiology · 2014Article
- The role of dendritic cells in the innate recognition of pathogenic fungi (A. fumigatus, C. neoformans and C. albicans).Virulence · 2012Review
- Human genetic susceptibility to Candida infections.Medical mycology · 2012Review
- Review
- C-type lectin receptors and RIG-I-like receptors: new points on the oncogenomics map.Cancer management and research · 2012Article
- Immunity to fungal infections.Nature reviews. Immunology · 2011Review
- Distribution and antifungal susceptibility profile of oropharyngealTherapeutic advances in infectious diseaseArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 5 institutions in 4 countries.
Funding
Abstract
backgroundThe occurrence of oropharyngeal candidiasis (OPC) in combination with HIV disease progression is a very common phenomenon. However, not all HIV-infected patients develop OPC, even when they progress to low CD4 T-cell counts. Because T-cell immunity is defective in AIDS, the innate defence mechanisms are likely to have a central role in antifungal immunity in these patients. We investigated whether genetic variations in the innate immune genes DECTIN-1, TLR2, TLR4, TIRAP, and CASPASE-12 are associated with the presence of OPC in HIV-infected subjects from East Africa.
methodsA total of 225 HIV patients were genotyped for several single nucleotide polymorphisms (SNPs), and this was correlated with the occurrence of OPC in these patients. In addition, primary immune cells obtained from individuals with different genotypes were stimulated with Candida albicans, and cytokine production was measured.
resultsThe analysis revealed that no significant differences in the polymorphism frequencies could be observed, although a tendency toward a protective effect on OPC of the DECTIN-1 I223S SNP was apparent. Furthermore, interferon gamma production capacity was markedly lower in cells bearing the DECTIN-1 SNP I223S. It could also be demonstrated that the 223S mutated form of the DECTIN-1 gene exhibits a lower capacity to bind zymosan.
conclusionsThese data demonstrate that common polymorphisms of TLR2, TLR4, TIRAP, and CASPASE-12 do not influence susceptibility to OPC in HIV-infected patients in East Africa but suggest an immunomodulatory effect of the I223S SNP on dectin-1 function and possibly the susceptibility to OPC in HIV patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.