ArticleCirculation research2010
Inhibition of bone morphogenetic proteins protects against atherosclerosis and vascular calcification.
Article in Circulation research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 130 papers, 1 of them a synthesis that pooled it.
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Who cites it
130 citing papers in PubMed, 1 synthesis or guideline pooled it, 250 citations in OpenAlex.
- Molecular Interactions Between Vascular Smooth Muscle Cells and Macrophages in Atherosclerosis.Frontiers in cardiovascular medicine · 2021Pooled it
- Vitamin K status and vascular calcification biomarkers as determinants of carotid plaque in peritoneal dialysis: a prospective study.Renal failure · 2026Article
- Nedd4L-mediated stabilization of morphogenetic protein receptor 2 in lung fibroblasts confers protection against pulmonary fibrosis.Signal transduction and targeted therapy · 2026Article
- Matrix Gla Protein is a novel regulator of TGFβ-dependent fibroblast activation and kidney fibrosis.Molecular biomedicine · 2026Article
- Decoding brain arteriovenous malformations: from genetic insights to modeling the vascular maze.Acta neuropathologica communications · 2026Review
- Considerations in the Use of Mouse Models of Vascular and Valvular Calcification.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Zinc Action in Vascular Calcification.Preventive nutrition and food science · 2024Review
- CDK1 inhibition reduces osteogenesis in endothelial cells in vascular calcification.JCI insight · 2024Article
- GSK3β Inhibition Ameliorates Atherosclerotic Calcification.International journal of molecular sciences · 2023Article
- GSK3β Inhibition Reduced Vascular Calcification inInternational journal of molecular sciences · 2023Article
- Extracellular vesicles in atherosclerosis and vascular calcification: the versatile non-coding RNAs from endothelial cells and vascular smooth muscle cells.Frontiers in medicine · 2023Review
- Atheroprone fluid shear stress-regulated ALK1-Endoglin-SMAD signaling originates from early endosomes.BMC biology · 2022Article
- Identification of Risk Factors in the Development of Heterotopic Ossification After Primary Total Hip Arthroplasty.The Journal of clinical endocrinology and metabolism · 2022Article
- Programmed cell death in atherosclerosis and vascular calcification.Cell death & disease · 2022Review
- Role of endothelial cells in vascular calcification.Frontiers in cardiovascular medicine · 2022Review
- Vascular Calcification: New Insights Into BMP Type I Receptor A.Frontiers in pharmacology · 2022Review
- The vascular protective effect of matrix Gla protein during kidney injury.Frontiers in molecular medicine · 2022Review
- Relationship between Structure and Biological Activity of Various Vitamin K Forms.Foods (Basel, Switzerland) · 2021Review
- Defining matrix Gla protein expression in the Dunkin-Hartley guinea pig model of spontaneous osteoarthritis.BMC musculoskeletal disorders · 2021Article
- The biology of bone morphogenetic protein signaling pathway in cerebrovascular system.Chinese neurosurgical journal · 2021Review
70 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
rationaleThe bone morphogenetic proteins (BMPs), a family of morphogens, have been implicated as mediators of calcification and inflammation in the vascular wall.
objectiveTo investigate the effect of altered expression of matrix Gla protein (MGP), an inhibitor of BMP, on vascular disease. METHODS AND
resultsWe used MGP transgenic or MGP-deficient mice bred to apolipoprotein E mice, a model of atherosclerosis. MGP overexpression reduced vascular BMP activity, atherosclerotic lesion size, intimal and medial calcification, and inflammation. It also reduced expression of the activin-like kinase receptor 1 and the vascular endothelial growth factor, part of a BMP-activated pathway that regulates angiogenesis and may enhance lesion formation and calcification. Conversely, MGP deficiency increased BMP activity, which may explain the diffuse calcification of vascular medial cells in MGP deficient aortas and the increase in expression of activin-like kinase receptor 1 and vascular endothelial growth factor. Unexpectedly, atherosclerotic lesion formation was decreased in MGP-deficient mice, which may be explained by a dramatic reduction in expression of endothelial adhesion molecules limiting monocyte infiltration of the artery wall.
conclusionsOur results indicate that BMP signaling is a key regulator of vascular disease, requiring careful control to maintain normal vascular homeostasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.