ArticleClinical journal of the American Society of Nephrology : CJASN2010
Long-term treatment with potassium citrate and renal stones in medullary sponge kidney.
Article in Clinical journal of the American Society of Nephrology : CJASN, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03007160 (A Randomized, Blank Controlled, Multicenter Clinical Trial of the Effection of Potassium Citrate Extended-release Tablets on Urolithiasis Formation or Recurrence), which is not on this map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized, Blank Controlled, Multicenter Clinical Trial of the Effection of Potassium Citrate Extended-release Tablets on Urolithiasis Formation or Recurrence
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.
- Metabolic diagnosis and medical prevention of calcium nephrolithiasis and its systemic manifestations: a consensus statement.Journal of nephrology · 2016Guideline
- The efficacy and safety of citrate mixture vs sodium bicarbonate on urine alkalization in Chinese primary gout patients with benzbromarone: a prospective, randomized controlled study.Rheumatology (Oxford, England) · 2021Trial
- Impact of Potassium Citrate vs Citric Acid on Urinary Stone Risk in Calcium Phosphate Stone Formers.The Journal of urology · 2018Trial
- Urolithiasis in patients with cancer.Nature reviews. Urology · 2026Review
- Calcium Phosphate Nephrolithiasis: A Comprehensive Review.Kidney medicine · 2026Review
- Medullary sponge kidney: in-depth phenotyping for a better understanding of functional and structural abnormalities.Journal of nephrology · 2025Article
- Porous perspectives: a comprehensive review of medullary sponge kidney.International urology and nephrology · 2025Review
- Characterization of Stone Events in Patients With Type 3 Primary Hyperoxaluria.The Journal of urology · 2023Article
- Curcumin alleviated oxidation stress injury by mediating osteopontin in nephrolithiasis rats.Acta cirurgica brasileira · 2023Article
- The SLC6A19 gene mutation in a young man with hyperglycinuria and nephrolithiasis: a case report and literature review.BMC urology · 2022Review
- Hypocitraturia is present when renal function is impaired in diverse nephropathies and is not related with serum bicarbonate levels.International urology and nephrology · 2022Article
- Single-Cell Gene Expression Analysis in Patients with Medullary Sponge Kidney and a Retrospective Study.BioMed research international · 2022Article
- Distal renal tubular acidosis: a systematic approach from diagnosis to treatment.Journal of nephrology · 2021Review
- Impact of potassium citrate on urinary risk profile, glucose and lipid metabolism of kidney stone formers in Switzerland.Clinical kidney journal · 2020Article
- Ambiguous clear cell carcinoma in medullary sponge kidney: A case report.Asian journal of urology · 2020Article
- ChlorthalidoneAnnals of translational medicine · 2019Article
- Living kidney donation from people at risk of nephrolithiasis, with a focus on the genetic forms.Urolithiasis · 2019Review
- Nephrocalcinosis in adolescent girl with medullary sponge kidney and mild hemihypertrophy: A case report.Medicine · 2019Article
- Medullary Sponge Kidney: Current Perspectives.International journal of nephrology and renovascular disease · 2019Article
- Chronic pain in medullary sponge kidney: a rare and never described clinical presentation.Journal of nephrology · 2018Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesMedullary sponge kidney (MSK) is a renal malformation typically associated with nephrocalcinosis and recurrent calcium stones. Incomplete distal renal tubular acidosis, hypocitraturia, and hypercalciuria are common. For stone prevention, patients with MSK generally receive the standard "stone clinic" recommendations and often receive potassium citrate (KC). However, the effect on stone recurrence of citrate treatment in these patients has never been studied. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: The issue was retrospectively analyzed on an outpatient basis in 97 patients with a radiologic diagnosis of MSK: 65 had at least one stone risk factor (SRF; hypercalciuria, hypocitraturia, hyperuricosuria, hyperoxaluria) and received KC [29 +/- 8 (SD) mEq/d]; 10 patients with SRF and 22 without received only general stone clinic suggestions. Follow-up was 78 +/- 13, 72 +/- 15, and 83 +/- 14 months, respectively. The 24-hour urinary excretion of calcium, oxalate, uric acid, citrate, and morning urine pH were investigated at baseline and at the end of follow-up.
resultsParallel to a significant rise in urinary citrate and decreased urinary calcium (all P < 0.001), KC led to a dramatic reduction in the stone event rate (from 0.58 to 0.10 stones/yr per patient). The existence of a group of patients with MSK, those without SRF, with a very low stone rate and no SRF was recognized.
conclusionsTreatment with KC is effective in preventing renal stones in the typical patient with MSK. It seems that two clinical phenotypes among patients showing typical MSK features during radiologic study exist.
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