Evidence map›Paper›PMID 20576648›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2010

Age-related changes in scavenger receptor-mediated endocytosis in rat liver sinusoidal endothelial cells.

Jaione Simon-Santamaria, Ivana Malovic, Alessandra Warren, Ana Oteiza, David Le Couteur, Bård Smedsrød, Peter McCourt, Karen Kristine Sørensen

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 68 citations in OpenAlex.

  1. The Scavenger Function of LSECs, a Regulator of Liver Diseases.Current issues in molecular biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Jaione Simon-SantamariaDepartment of Medical Biology, University of Tromsø, NO-9037 Tromsø, Norway.
Ivana Malovic
Alessandra Warren
Ana Oteiza
David Le Couteur
Bård Smedsrød
Peter McCourt
Karen Kristine Sørensen
UiT The Arctic University of Norway · NOUniversity of Sydney · AU

Funding

Aging and Hepatic Microvascular DysfunctionR21AG026582 · NIA · UNIVERSITY OF ARIZONA · PI MCCUSKEY, ROBERT S · 2006 to 2007
$268k
NIA NIH HHS 1 R21 AG026582-01A1NIA NIH HHS R21 AG026582
6 · The paper itself

Abstract

Liver sinusoidal endothelial cells (LSECs) play an essential role in systemic waste clearance by effective endocytosis of blood-borne waste macromolecules. We aimed to study LSECs' scavenger function during aging, and whether age-related morphological changes (eg, defenestration) affect this function, in F344/BN F1 rats. Endocytosis of the scavenger receptor ligand formaldehyde-treated serum albumin was significantly reduced in LSECs from old rats. Ligand degradation, LSEC protein expression of the major scavenger receptors for formaldehyde-treated serum albumin endocytosis, stabilin-1 and stabilin-2, and their staining patterns along liver sinusoids, was similar at young and old age, suggesting that other parts of the endocytic machinery are affected by aging. Formaldehyde-treated serum albumin uptake per cell, and cell porosity evaluated by electron microscopy, was not correlated, indicating that LSEC defenestration is not linked to impaired endocytosis. We report a significantly reduced LSEC endocytic capacity at old age, which may be especially important in situations with increased circulatory waste loads.

Indexed as

EndocytosisAgingAnimalsCell Adhesion Molecules, NeuronalCells, CulturedEndothelial CellsFormaldehydeLiverMaleMicroscopy, ConfocalMicroscopy, Electron, ScanningMicroscopy, Electron, TransmissionRatsRats, Inbred F344Receptors, Cell SurfaceSerum Albumin, BovineCell Adhesion Molecules, NeuronalFormaldehydeReceptors, Cell SurfaceSerum Albumin, BovineStab1 protein, mouseStab2 protein, mouse

Identifiers

PMID20576648
PMCPMC2920583
OpenAlexW2131563555

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.