ReviewInternational journal of psychophysiology : official journal of the International Organization of Psychophysiology2010
The psychophysiology of blood-injection-injury phobia: looking beyond the diphasic response paradigm.
Review in International journal of psychophysiology : official journal of the International Organization of Psychophysiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- Interventions for Individuals With High Levels of Needle Fear: Systematic Review of Randomized Controlled Trials and Quasi-Randomized Controlled Trials.The Clinical journal of pain · 2015Pooled it
- Social Contagion of Vasovagal Symptoms in Blood Donors: Interactions With Empathy.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2022Trial
- Risk Factors for Vasovagal Reactions during Nonoperative Orthopedic Interventions in Outpatient Clinics: A Clinical Evaluation of 1,208 Patients.Clinics in orthopedic surgery · 2026Article
- Many labels, shared threat processes: classifying domain-labelled anxieties by mechanism rather than context.Psychoradiology · 2026Review
- Factors associated with documented distress during venipuncture in routine health checkups.Frontiers in psychiatry · 2026Article
- FactFinders for patient safety: Preventing potential procedure-related complications: Vasovagal reactions and spinal cord stimulator lead migration.Interventional pain medicine · 2023Article
- Predicting vasovagal reactions to needles with anticipatory facial temperature profiles.Scientific reports · 2023Article
- High Interest in Long-acting Injectable Pre-exposure Prophylaxis (LAI-PrEP) for HIV Prevention Among Men Who Have Sex With Men (MSM): Result From A Nationwide Survey in Malaysia.Journal of community health · 2023Article
- The role of self-efficacy in specific fears.PloS one · 2023Article
- Article
- Combined Fainting and Psychogenic Non-epileptic Seizures as Significant Therapy Hurdles in Blood-Injury-Injection Phobia: A Mini-Review and Case Report.Frontiers in psychiatry · 2022Article
- The clinical characterization of the adult patient with an anxiety or related disorder aimed at personalization of management.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2021Article
- Cognitive Biases in Blood-Injection-Injury Phobia: A Review.Frontiers in psychiatry · 2021Review
- Effects of respiratory and applied muscle tensing interventions on responses to a simulated blood draw among individuals with high needle fear.Journal of behavioral medicine · 2018Article
- Typical vasovagal syncope as a "defense mechanism" for the heart by contrasting sympathetic overactivity.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2017Review
- Phlebotomy, a bridge between laboratory and patient.Biochemia medica · 2016Review
- One Session Treatment for Specific Phobias: An Adaptation for Paediatric Blood-Injection-Injury Phobia in Youth.Clinical child and family psychology review · 2015Review
- Awareness and performance of blood transfusion standards in operating rooms of Shiraz hospitals in 2012.Iranian journal of pediatric hematology and oncology · 2015Article
- Blood injury and injection phobia: the neglected one.Behavioural neurology · 2014Article
- Dysfunctional breathing phenotype in adults with asthma - incidence and risk factors.Clinical and translational allergy · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Blood-injection-injury (BII) phobia is an anxiety disorder that may be accompanied by vasovagal fainting during confrontation with the feared stimuli. The underlying pattern of autonomic regulation has been characterized as a diphasic response, with initial increases in heart rate and blood pressure that are typical of a fight-flight response, and subsequent drops in blood pressure and/or heart rate that may precipitate vasovagal fainting. Tensing skeletal muscles of the arms, legs, and trunk (applied tension) has been proposed as a technique to cope with this dysregulation. This review critically examines the empirical basis for the diphasic response and its treatment by applied tension in BII phobia. An alternative perspective on the psychophysiology of BII phobia and vasovagal fainting is offered by focusing on hypocapnia that leads to cerebral blood flow reductions, a perspective supported by research on neurocardiogenic and orthostatically-induced syncope. The evidence may indicate a role for respiration-focused coping techniques in BII phobia.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.