ArticleDiabetology & metabolic syndrome2010
Combination therapy in hypertension: An update.
Article in Diabetology & metabolic syndrome, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 105 citations in OpenAlex.
- Medication adherence with fixed-doseFrontiers in pharmacology · 2023Pooled it
- Cost-effectiveness Analyses of Antihypertensive Medicines: A Systematic Review.American journal of preventive medicine · 2017Pooled it
- Bioequivalence and Food Effect Assessment of Two Fixed-Dose Combination Formulations of Telmisartan-Hydrochlorothiazide Tablets in Chinese Healthy Subjects.Clinical and translational science · 2025Trial
- Fixed-dose combination pharmacologic therapy to improve hypertension control worldwide: Clinical perspective and policy implications.Journal of clinical hypertension (Greenwich, Conn.) · 2019Trial
- CONTROL-IHD Study: 24-h BP Control with Metoprolol-Telmisartan FDC in Hypertension and Stable Ischemic Disease.Advances in therapy · 2026Article
- Risk of Acute Infections in New Users of Antihypertensive Drugs: An Observational Cohort Study.Journal of the American Heart Association · 2025Observational
- Multivariate Joint Analysis of Blood Pressure Measurements and Time to Remission: A Case Study of Hypertensive Patients Receiving Treatment at Jimma University Medical Center.Journal of research in health sciences · 2025Article
- Article
- Longitudinal association of hypertension and dyslipidemia with cognitive function in community-dwelling older adults: the SONIC study.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Observational
- Article
- Investigation of the synergistic effect of glimepiride and rosuvastatin on alloxan-induced diabetic rat.Journal of diabetes and metabolic disorders · 2020Article
- Affordability Assessment from a Static to Dynamic Concept: A Scenario-Based Assessment of Cardiovascular Medicines.International journal of environmental research and public health · 2020Article
- Counter-regulatory renin-angiotensin system in cardiovascular disease.Nature reviews. Cardiology · 2020Review
- Blood pressure and low-density lipoprotein cholesterol control status in Chinese hypertensive dyslipidemia patients during lipid-lowering therapy.Lipids in health and disease · 2019Article
- Effect ofAdvanced pharmaceutical bulletin · 2018Article
- Jet dispensing of multi-layered films for the co-delivery of three antihypertensive agents.Drug delivery and translational research · 2018Article
- A Study to Assess the Therapeutic Effect of Enalapril on Olanzapine Induced Metabolic Syndrome in Wistar Rats.Journal of clinical and diagnostic research : JCDR · 2017Article
- Blood pressure-decreasing effect of etamicastat alone and in combination with antihypertensive drugs in the spontaneously hypertensive rat.Hypertension research : official journal of the Japanese Society of Hypertension · 2015Article
- Conceptuation, formulation and evaluation of sustained release floating tablets of captopril compression coated with gastric dispersible hydrochlorothiazide using 2(3) factorial design.International journal of pharmaceutical investigation · 2014Article
- Antihypertensive combination therapy in primary care offices: results of a cross-sectional survey in Switzerland.International journal of general medicine · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Meticulous control of blood pressure is required in patients with hypertension to produce the maximum reduction in clinical cardiovascular end points, especially in patients with comorbidities like diabetes mellitus where more aggressive blood pressure lowering might be beneficial. Recent clinical trials suggest that the approach of using monotherapy for the control of hypertension is not likely to be successful in most patients. Combination therapy may be theoretically favored by the fact that multiple factors contribute to hypertension, and achieving control of blood pressure with single agent acting through one particular mechanism may not be possible. Regimens can either be fixed dose combinations or drugs added sequentially one after other. Combining the drugs makes them available in a convenient dosing format, lower the dose of individual component, thus, reducing the side effects and improving compliance. Classes of antihypertensive agents which have been commonly used are angiotensin receptor blockers, thiazide diuretics, beta and alpha blockers, calcium antagonists and angiotensin-converting enzyme inhibitors. Thiazide diuretics and calcium channel blockers are effective, as well as combinations that include renin-angiotensin-aldosterone system blockers, in reducing BP. The majority of currently available fixed-dose combinations are diuretic-based. Combinations may be individualized according to the presence of comorbidities like diabetes mellitus, chronic renal failure, heart failure, thyroid disorders and for special population groups like elderly and pregnant females.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.