ArticleBMC immunology2010
Mast cell repopulation of the peritoneal cavity: contribution of mast cell progenitors versus bone marrow derived committed mast cell precursors.
Article in BMC immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- Role of Mast Cells in Human Health and Disease: Controversies and Novel Therapies.International journal of molecular sciences · 2025Review
- Mast Cells Modulate the Immune Response and Redox Status of the Gastrointestinal Tract in Induced Venom Pathogenesis.Inflammation · 2022Article
- Mast cells: Therapeutic targets for COVID-19 and beyond.IUBMB life · 2021Review
- Mast Cell Biology at Molecular Level: a Comprehensive Review.Clinical reviews in allergy & immunology · 2020Review
- The effect of laparoscopy on mast cell degranulation and mesothelium thickness in rats.BMC surgery · 2020Article
- Deciphering the differentiation trajectory from hematopoietic stem cells to mast cells.Blood advances · 2018Review
- Mast Cell, the Neglected Member of the Tumor Microenvironment: Role in Breast Cancer.Journal of immunology research · 2018Review
- Pressure overload leads to an increased accumulation and activity of mast cells in the right ventricle.Physiological reports · 2017Article
- Distinguishing Mast Cell Progenitors from Mature Mast Cells in Mice.Stem cells and development · 2015Article
- The role of Lin28b in myeloid and mast cell differentiation and mast cell malignancy.Leukemia · 2015Article
- Immune targeting of the pleural space by intercostal approach.BMC pulmonary medicine · 2015Article
- Mast cell function: a new vision of an old cell.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2014Review
- Bone marrow mast cell density correlates with serum levels of VEGF and CXC chemokines ENA-78 and GRO-α in multiple myeloma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Committed mast cell progenitors in mouse blood differ in maturity between Th1 and Th2 strains.Allergy · 2013Article
- Gross morphological features of the organ surface primo-vascular system revealed by hemacolor staining.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Rat embryonic mast cells originate in the AGM.PloS one · 2013Article
- Stem cell factor is responsible for the rapid response in mature mast cell density in the acutely stressed heart.Journal of molecular and cellular cardiology · 2012Article
- Expression of mast cell proteases correlates with mast cell maturation and angiogenesis during tumor progression.PloS one · 2012Article
- Cardiac mast cells: the centrepiece in adverse myocardial remodelling.Cardiovascular research · 2011Review
- The mast cell reaction in premalignant and malignant lesions of the head and neck.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMast cells have recently gained new importance as immunoregulatory cells that are involved in numerous pathological processes. One result of these processes is an increase in mast cell numbers at peripheral sites. This study was undertaken to determine the mast cell response in the peritoneal cavity and bone marrow during repopulation of the peritoneal cavity in rats.
resultsTwo mast cell specific antibodies, mAb AA4 and mAb BGD6, were used to distinguish the committed mast cell precursor from more mature mast cells. The peritoneal cavity was depleted of mast cells using distilled water. Twelve hours after distilled water injection, very immature mast cells could be isolated from the blood and by 48 hours were present in the peritoneal cavity. At this same time the percentage of mast cells in mitosis increased fourfold. Mast cell depletion of the peritoneal cavity also reduced the total number of mast cells in the bone marrow, but increased the number of mast cell committed precursors.
conclusionsIn response to mast cell depletion of the peritoneal cavity, a mast cell progenitor is released into the circulation and participates in repopulation of the peritoneal cavity, while the committed mast cell precursor is retained in the bone marrow.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.