ArticleTransfusion2010
Enhanced classification of Chagas serologic results and epidemiologic characteristics of seropositive donors at three large blood centers in Brazil.
Article in Transfusion, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Bimodal distributions of anti-Trypanosoma cruzi antibody levels in blood donors are associated with parasite detection and antibody waning in peripheral blood.PLoS neglected tropical diseases · 2025Article
- Health literacy assessment of individuals with and without Chagas disease: a cross-sectional study.BMC infectious diseases · 2024Article
- Cardiac involvement in Chagas disease and African trypanosomiasis.Nature reviews. Cardiology · 2024Review
- Prevalence of Trypanosoma Cruzi Infection in Blood Donors.Arquivos brasileiros de cardiologia · 2020Article
- Declining antibody levels to Trypanosoma cruzi correlate with polymerase chain reaction positivity and electrocardiographic changes in a retrospective cohort of untreated Brazilian blood donors.PLoS neglected tropical diseases · 2020Article
- Lack of evidence of seronegative infection in an endemic area of Chagas disease.Revista do Instituto de Medicina Tropical de Sao Paulo · 2019Article
- Mortality among blood donors seropositive and seronegative for Chagas disease (1996-2000) in São Paulo, Brazil: A death certificate linkage study.PLoS neglected tropical diseases · 2017Article
- Development of a Novel Multiplex Immunoassay Multi-cruzi for the Serological Confirmation of Chagas Disease.PLoS neglected tropical diseases · 2016Article
- Article
- Contribution of the Retrovirus Epidemiology Donor Study (REDS) to research on blood transfusion safety in Brazil.Revista brasileira de hematologia e hemoterapia · 2014Article
- Article
- Methodological Guidelines for Reducing the Complexity of Data Warehouse Development for Transactional Blood Bank Systems.Decision support systems · 2013Article
- Electrocardiographic abnormalities in Trypanosoma cruzi seropositive and seronegative former blood donors.PLoS neglected tropical diseases · 2013Article
- The National Heart, Lung, and Blood Institute retrovirus epidemiology donor studies (Retrovirus Epidemiology Donor Study and Retrovirus Epidemiology Donor Study-II): twenty years of research to advance blood product safety and availability.Transfusion medicine reviews · 2012Article
- Performance of six diagnostic tests to screen for Chagas disease in blood banks andprevalence of Trypanosoma cruzi infection among donors with inconclusive serologyscreening based on the analysis of epidemiological variables.Revista brasileira de hematologia e hemoterapia · 2012Article
- Anti-Trypanosoma cruzi inconclusive results in blood donor screening.Revista brasileira de hematologia e hemoterapia · 2012Article
- Trypanosoma cruzi and Chagas' Disease in the United States.Clinical microbiology reviews · 2011Review
- Chagas disease: Performance analysis of immunodiagnostic tests anti-Trypanosoma cruzi in blood donors with inconclusive screening results.Hematology, transfusion and cell therapyArticle
- Chagasic infection among blood donors in Brazil: an integrative review.Hematology, transfusion and cell therapyReview
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 2 countries.
Funding
Abstract
backgroundA major problem in Chagas disease donor screening is the high frequency of samples with inconclusive results. The objective of this study was to describe patterns of serologic results among donors to the three Brazilian REDS-II blood centers and correlate with epidemiologic characteristics. STUDY DESIGN AND
methodsThe centers screened donor samples with one Trypanosoma cruzi lysate enzyme immunoassay (EIA). EIA-reactive samples were tested with a second lysate EIA, a recombinant-antigen based EIA, and an immunfluorescence assay. Based on the serologic results, samples were classified as confirmed positive (CP), probable positive (PP), possible other parasitic infection (POPI), and false positive (FP).
resultsIn 2007 to 2008, a total of 877 of 615,433 donations were discarded due to Chagas assay reactivity. The prevalences (95% confidence intervals [CIs]) among first-time donors for CP, PP, POPI, and FP patterns were 114 (99-129), 26 (19-34), 10 (5-14), and 96 (82-110) per 100,000 donations, respectively. CP and PP had similar patterns of prevalence when analyzed by age, sex, education, and location, suggesting that PP cases represent true T. cruzi infections; in contrast the demographics of donors with POPI were distinct and likely unrelated to Chagas disease. No CP cases were detected among 218,514 repeat donors followed for a total of 718,187 person-years.
conclusionWe have proposed a classification algorithm that may have practical importance for donor counseling and epidemiologic analyses of T. cruzi-seroreactive donors. The absence of incident T. cruzi infections is reassuring with respect to risk of window phase infections within Brazil and travel-related infections in nonendemic countries such as the United States.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.