ArticleThe Journal of comparative neurology2010
Organization of amyloid-beta protein precursor intracellular domain-associated protein-1 in the rat brain.
Article in The Journal of comparative neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Predicting functional outcome in ischemic stroke patients using genetic, environmental, and clinical factors: a machine learning analysis of population-based prospective cohort study.Briefings in bioinformatics · 2024Article
- ANKS1B encoded AIDA-1 regulates social behaviors by controlling oligodendrocyte function.Nature communications · 2023Article
- The Structural Dynamics, Complexity of Interactions, and Functions in Cancer of Multi-SAM Containing Proteins.Cancers · 2023Review
- Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling.The Journal of biological chemistry · 2021Article
- Haploinsufficiency in the ANKS1B gene encoding AIDA-1 leads to a neurodevelopmental syndrome.Nature communications · 2019Article
- ThePharmacogenomics · 2019Review
- Explorative results from multistep screening for potential genetic risk loci of Alzheimer's disease in the longitudinal VITA study cohort.Journal of neural transmission (Vienna, Austria : 1996) · 2018Article
- CaMKII-mediated displacement of AIDA-1 out of the postsynaptic density core.FEBS letters · 2016Article
- The Postsynaptic Density: There Is More than Meets the Eye.Frontiers in synaptic neuroscience · 2016Article
- ANKS1B Gene Product AIDA-1 Controls Hippocampal Synaptic Transmission by Regulating GluN2B Subunit Localization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Quantitative mass spectrometry measurements reveal stoichiometry of principal postsynaptic density proteins.Journal of proteome research · 2015Article
- Article
- Chronic ethanol up-regulates the synaptic expression of the nuclear translational regulatory protein AIDA-1 in primary hippocampal neurons.Alcohol (Fayetteville, N.Y.) · 2012Article
- Ultrastructure of synapses in the mammalian brain.Cold Spring Harbor perspectives in biology · 2012Review
- Synapse-to-nucleus signaling.Current opinion in neurobiology · 2011Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Sustained activity-dependent synaptic modifications require protein synthesis. Although proteins can be synthesized locally in dendrites, long-term changes also require nuclear signaling. Amyloid-beta protein precursor intracellular domain-associated protein-1 (AIDA-1), an abundant component of the biochemical postsynaptic density fraction, contains a nuclear localization sequence, making it a plausible candidate for synapse-to-nucleus signaling. We used immunohistochemistry to study the regional, cellular, and subcellular distribution of AIDA-1. Immunostaining was prominent in the hippocampus, cerebral cortex, and neostriatum. Along with diffuse staining of neuropil, fluorescence microscopy revealed immunostaining of excitatory synapses throughout the forebrain, and immunoreactive puncta within and directly outside the nucleus. Presynaptic staining was conspicuous in hippocampal mossy fibers. Electron microscopic analysis of material processed for postembedding immunogold revealed AIDA-1 label within postsynaptic densities in both hippocampus and cortex. Together with previous work, these data suggest that AIDA-1 serves as a direct signaling link between synapses and the nucleus in adult rat brain.
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Registered trials
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