ReviewPflugers Archiv : European journal of physiology2010
Role of ERG1 isoforms in modulation of ERG1 channel trafficking and function.
Review in Pflugers Archiv : European journal of physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- hERG1 channel subunit composition mediates proton inhibition of rapid delayed rectifier potassium current (IThe Journal of biological chemistry · 2023Article
- Neuroblastoma SH-SY5Y Cell Differentiation to Mature Neuron by AM580 Treatment.Neurochemical research · 2022Article
- Celebrities in the heart, strangers in the pancreatic beta cell: Voltage-gated potassium channels KActa physiologica (Oxford, England) · 2022Review
- Gq-Coupled Muscarinic Receptor Enhancement of KCNQ2/3 Channels and Activation of TRPC Channels in Multimodal Control of Excitability in Dentate Gyrus Granule Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Regulation of Kv11.1 potassium channel C-terminal isoform expression by the RNA-binding proteins HuR and HuD.The Journal of biological chemistry · 2018Article
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- Oxidative modulation of voltage-gated potassium channels.Antioxidants & redox signaling · 2014Review
- Identification of Kv11.1 isoform switch as a novel pathogenic mechanism of long-QT syndrome.Circulation. Cardiovascular genetics · 2014Article
- Impact of NPR-A expression in gastric cancer cells.International journal of clinical and experimental medicine · 2014Article
- High potency inhibition of hERG potassium channels by the sodium-calcium exchange inhibitor KB-R7943.British journal of pharmacology · 2012Article
- Alternative splicing and polyadenylation contribute to the generation of hERG1 C-terminal isoforms.The Journal of biological chemistry · 2010Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The 'ether-a-go-go-related' gene type 1 (ERG1 or Kv11.1) protein is the product of the KCNH2 gene. Currents generated by ERG1 channels are important in a range of tissues including neuronal, smooth muscle, and cardiac tissues, as well as in cancer cells. There are five known isoforms of the ERG1 protein. Overlapping patterns of endogenous expression of ERG1 isoforms have been described in several tissue types. Abnormal changes in the relative abundance of ERG1 isoforms may result in disease. Recent studies have suggested that the different isoforms play a prominent role in expression and trafficking of ERG1 channels as well as in modulating the electrophysiological properties of the channels. This review focuses on the differences between the ERG1 isoforms and describes the physiological implications thereof. It is described how changes in the relative expression level of the isoforms may have significant physiological consequences by modulation of tissue excitability. Additionally, the review proposes a standardized nomenclature of ERG1 isoforms based on their structural features.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.