ArticleJournal of molecular medicine (Berlin, Germany)2010
MIR152, MIR200B, and MIR338, human positional and functional neuroblastoma candidates, are involved in neuroblast differentiation and apoptosis.
Article in Journal of molecular medicine (Berlin, Germany), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Modulation of all-trans retinoic acid-induced MiRNA expression in neoplastic cell lines: a systematic review.BMC cancer · 2019Pooled it
- Oncogenic functions of ZEB1 in pediatric solid cancers: interplays with microRNAs and long noncoding RNAs.Molecular and cellular biochemistry · 2021Review
- The Potential Role of miRNAs as Predictive Biomarkers in Neurodevelopmental Disorders.Journal of molecular neuroscience : MN · 2021Review
- IGF2BP2 stabilized FBXL19-AS1 regulates the blood-tumour barrier permeability by negatively regulating ZNF765 by STAU1-mediated mRNA decay.RNA biology · 2020Article
- ATRA induces the differentiation of hepatic progenitor cells by upregulating microRNA-200a.In vitro cellular & developmental biology. Animal · 2019Article
- Function of miR-152 as a Tumor Suppressor in Human Breast Cancer by Targeting PIK3CA.Oncology research · 2017Article
- Article
- MicroRNA-338 Attenuates Cortical Neuronal Outgrowth by Modulating the Expression of Axon Guidance Genes.Molecular neurobiology · 2017Article
- Altered expression of miRNAs and methylation of their promoters are correlated in neuroblastoma.Oncotarget · 2016Article
- MiR-338-5p sensitizes glioblastoma cells to radiation through regulation of genes involved in DNA damage response.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- miR-152 as a tumor suppressor microRNA: Target recognition and regulation in cancer.Oncology letters · 2016Article
- Dysregulated miR-671-5p / CDR1-AS / CDR1 / VSNL1 axis is involved in glioblastoma multiforme.Oncotarget · 2016Article
- The MiRNA Journey from Theory to Practice as a CNS Biomarker.Frontiers in genetics · 2016Review
- Ionizing radiation-induced microRNA expression changes in cultured RGC-5 cells.Molecular medicine reports · 2015Article
- Circulating miRNAs profiles in Tourette syndrome: molecular data and clinical implications.Molecular brain · 2015Article
- miR-338-3p is over-expressed in blood, CFS, serum and spinal cord from sporadic amyotrophic lateral sclerosis patients.Neurogenetics · 2014Article
- MicroRNAs in neuroblastoma: small-sized players with a large impact.Neurochemical research · 2014Review
- Epigenetic deregulation of microRNAs in rhabdomyosarcoma and neuroblastoma and translational perspectives.International journal of molecular sciences · 2012Review
- Specific alterations of the microRNA transcriptome and global network structure in colorectal cancer after treatment with MAPK/ERK inhibitors.Journal of molecular medicine (Berlin, Germany) · 2012Article
- Genome-wide promoter methylation analysis in neuroblastoma identifies prognostic methylation biomarkers.Genome biology · 2012Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs (MIRs) perform critical regulatory functions within cell networks, both in physiology as well as in pathology. Through the positional gene candidate approach, we have identified three MIRs (MIR152, MIR200B, and MIR338) that are located in regions frequently altered in neuroblastoma (NB) and target mRNAs encoding proteins involved in cell proliferation, neuroblast differentiation, neuroblast migration, and apoptosis. Expression analysis in NB biopsies and NB cell lines showed that these MIRs are dysregulated. We have characterized a CpG island, close to the gene encoding MIR200B and hypermethylated in NB samples, that explains its negative regulation. Expression of MIR152, MIR200B, and MIR338 is specifically modulated in NB cell lines during differentiation and apoptosis. Functional genomic experiments through enforced expression of MIR200B and knockdown of MIR152 resulted in a significant decrease of the invasion activity of SH-SY5Y cells. Reconstruction of a NB network comprising MIR152, MIR200B, and MIR338 allowed us to confirm their role in the control of NB cell stemness and apoptosis: This suggests that altered regulation of these MIRs could have a role in NB pathogenesis by interfering with the molecular mechanisms, which physiologically control differentiation and death of neuroblasts. Accordingly, they could be considered as new NB biomarkers and potential targets of antagomirs or epigenetic therapies.
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