ArticleEnvironmental geochemistry and health2011
Is selenium deficiency really the cause of Keshan disease?
Article in Environmental geochemistry and health, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Selenium nutritional status and cardiovascular diseases: mechanisms of cardioprotection and 21 years of global research trends in precision prevention (2005-2026).Frontiers in nutrition · 2026Pooled it
- Crucial Interactions between Altered Plasma Trace Elements and Fatty Acids Unbalance Ratio to Management of Systemic Arterial Hypertension in Diabetic Patients: Focus on Endothelial Dysfunction.International journal of molecular sciences · 2024Article
- Antioxidant and anti-inflammatory effects of selenomethionine promote osteogenesis via Wnt/β-Catenin pathway.Biochemistry and biophysics reports · 2023Article
- Mitochondrial Aging and Senolytic Natural Products with Protective Potential.International journal of molecular sciences · 2022Review
- Significant Nutritional Gaps in Tibetan Adults Living in Agricultural Counties Along Yarlung Zangbo River.Frontiers in nutrition · 2022Article
- The epidemiological status, environmental and genetic factors in the etiology of Keshan disease.Cardiovascular endocrinology & metabolism · 2021Review
- Association of CYP4F2 and CTRP9 polymorphisms and serum selenium levels with coronary artery disease.Medicine · 2020Article
- Selenium Biofortification of Crop Food by Beneficial Microorganisms.Journal of fungi (Basel, Switzerland) · 2020Review
- Cardiomyopathy Associated with Zinc Deficiency after Bariatric Surgery.The International journal of angiology : official publication of the International College of Angiology, Inc · 2019Article
- Environmental Selenium and Human Health: an Update.Current environmental health reports · 2018Review
- Health risk assessment of environmental selenium: Emerging evidence and challenges (Review).Molecular medicine reports · 2017Review
- Micronutrients and Leptospirosis: A Review of the Current Evidence.PLoS neglected tropical diseases · 2016Review
- Selenoproteins and heat shock proteins play important roles in immunosuppression in the bursa of Fabricius of chickens with selenium deficiency.Cell stress & chaperones · 2015Article
- Selenium: a brief review and a case report of selenium responsive cardiomyopathy.BMC pediatrics · 2013Review
- Review
- Oxidative stress is involved in the pathogenesis of Keshan disease (an endemic dilated cardiomyopathy) in China.Oxidative medicine and cellular longevity · 2013Article
- Selenium in the prevention of anthracycline-induced cardiac toxicity in children with cancer.Journal of oncology · 2012Article
- Arsenic exposure and motor function among children in Bangladesh.Environmental health perspectives · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Keshan disease (KD) is a dilated cardiomyopathy closely related with a diet deficient in the mineral selenium. It is named for the northeastern Chinese county Keshan, where the disease prevalence is high because of selenium-deficient soil. KD is a gene-environment interaction disease. Here, we used stepwise multiple regression analysis to analyze the risk factors of the disease and the main clinical features in 71 KD patients and 290 controls. The variables analyzed included age, sex, family history of KD, blood selenium level, glutathione peroxidase-1 (GPx-1) activity, variance at codon198 in GPx-1 gene, residence in an endemic area, abnormal electrocardiography (ECG) findings, and cardiothoracic (CT) ratio. The main risk factors found were low GPx-1 activity, family history of KD and living in an endemic area. The main clinical features were increased cardiac load on ECG and increased CT ratio and Tei index. Public health and clinical prevention efforts could focus on increasing GPx-1 activity to address KD. Is selenium deficiency really the certain cause of KD? This is not at all a settled question. And further study is promptly required to investigate the etiology of KD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.