Evidence map›Paper›PMID 20574543›Full record

ArticleCurrent fungal infection reports2010

Use of Antifungal Combination Therapy: Agents, Order, and Timing.

Melissa D Johnson, John R Perfect

Abstract read
In one paragraph

Article in Current fungal infection reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

  1. Article
  2. Beyond the usual suspects: fungal hypertrophic pachymeningitis with cranial neuropathies.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Chitosan-Deficient Cryptococcus as Whole-Cell Vaccines.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Fungal burn wound infection caused byAnnals of medicine and surgery (2012) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Melissa D JohnsonCampbell University College of Pharmacy & Health Sciences, Box 3306 DUMC, Durham, NC 27710, USA.
John R Perfect

Funding

Microfluidic PCR Platform to Detect Microbial DNAU01AI066590 · NIAID · DUKE UNIVERSITY · PI MITCHELL, THOMAS G. · 2005 to 2009
$3.0M
Host-Response Relationships in Patients with CandidemiaK23AI051537 · NIAID · DUKE UNIVERSITY · PI JOHNSON, MELISSA D · 2002 to 2006
$721k
NIAID NIH HHS K23 AI051537NIAID NIH HHS L30 AI057128NIAID NIH HHS U01 AI066590
6 · The paper itself

Abstract

Given the substantial morbidity and mortality related to invasive fungal infections, treatment with a combination of antifungal agents is often considered. A growing body of literature from in vitro studies, animal models, and clinical experience provides data evaluating this approach. This review describes combination antifungal strategies for the management of cryptococcal meningitis, invasive candidiasis, invasive aspergillosis, and rare mold infections. The potential effects that sequencing and timing have on the efficacy of such approaches are discussed, with a focus on recent clinical data in this arena.

Identifiers

PMID20574543
PMCPMC2889487

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.