ArticlePloS one2010
Concurrent helminthic infection protects schoolchildren with Plasmodium vivax from anemia.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Prevalence and effect of Plasmodium spp. and hookworm co-infection on malaria parasite density and haemoglobin level: a meta-analysis.Scientific reports · 2022Pooled it
- Severe vivax malaria: a systematic review and meta-analysis of clinical studies since 1900.Malaria journal · 2014Pooled it
- Understanding the clinical spectrum of complicated Plasmodium vivax malaria: a systematic review on the contributions of the Brazilian literature.Malaria journal · 2012Pooled it
- Ascaris co-infection does not alter malaria-induced anaemia in a cohort of Nigerian preschool children.Malaria journal · 2013Trial
- Integrated assessment of malaria parasite load, anemia, and associated factors in patients with and without soil-transmitted helminthes coinfection in Southern Ethiopia.Tropical diseases, travel medicine and vaccines · 2025Article
- Helminth-associated changes in host immune phenotype connect top-down and bottom-up interactions during co-infection.Functional ecology · 2023Article
- Impact of Plasmodium vivax malaria on executive and cognitive functions in elderlies in the Brazilian Amazon.Scientific reports · 2022Article
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- Article
- Relative Contribution of Schistosomiasis and Malaria to Anemia in Western Kenya.The American journal of tropical medicine and hygiene · 2018Article
- Article
- Global Epidemiology of Plasmodium vivax.The American journal of tropical medicine and hygiene · 2016Review
- Epidemiology of Plasmodium and Helminth Coinfection and Possible Reasons for Heterogeneity.BioMed research international · 2016Review
- Asymptomatic Vivax and Falciparum Parasitaemia with Helminth Co-Infection: Major Risk Factors for Anaemia in Early Life.PloS one · 2016Article
- The influence of intestinal parasites on Plasmodium vivax-specific antibody responses to MSP-119 and AMA-1 in rural populations of the Brazilian Amazon.Malaria journal · 2015Article
- Malaria-related anemia in patients from unstable transmission areas in Colombia.The American journal of tropical medicine and hygiene · 2015Article
- Potential immune mechanisms associated with anemia in Plasmodium vivax malaria: a puzzling question.Infection and immunity · 2014Review
- Co-infections of malaria and geohelminthiasis in two rural communities of Nkassomo and Vian in the Mfou health district, Cameroon.PLoS neglected tropical diseases · 2014Article
- Influence of age on the haemoglobin concentration of malaria-infected patients in a reference centre in the Brazilian Amazon.Memorias do Instituto Oswaldo Cruz · 2014Article
- Intestinal parasites coinfection does not alter plasma cytokines profile elicited in acute malaria in subjects from endemic area of Brazil.Mediators of inflammation · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPlasmodium vivax is responsible for a significant portion of malaria cases worldwide, especially in Asia and Latin America, where geo-helminthiasis have a high prevalence. Impact of the interaction between vivax malaria and intestinal helminthes has been poorly explored. The objective of this study was to evaluate the influence of intestinal helminthiasis on the concentration of hemoglobin in children with Plasmodium vivax malaria in rural areas in the municipality of Careiro, in the Western Brazilian Amazon. METHODOLOGY/PRINCIPAL
findingsA cohort study was conducted from April to November 2008, enrolling children from 5 to 14 years old in two rural areas endemic for malaria. A cross-sectional evaluation was performed in April to actively detect cases of malaria and document baseline hemoglobin and nutritional status. Children were followed-up for six months through passive case detection of malaria based on light microscopy. Throughout the follow-up interval, hemoglobin value and stool examination (three samples on alternate days) were performed on children who developed P. vivax malaria. For 54 schoolchildren with a single infection by P. vivax, hemoglobin during the malaria episode was similar to the baseline hemoglobin for children co-infected with Ascaris lumbricoides (n = 18), hookworm (n = 11) and Trichuris trichiura (n = 9). In children without intestinal helminthes, a significant decrease in the hemoglobin during the malarial attack was seen as compared to the baseline concentration. In the survival analysis, no difference was seen in the time (in days) from the baseline cross-sectional to the first malarial infection, between parasitized and non-parasitized children. CONCLUSION/SIGNIFICANCE: For the first time, a cohort study showed that intestinal helminthes protect against hemoglobin decrease during an acute malarial attack by P. vivax.
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Registered trials
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