Evidence map›Paper›PMID 20574417›Full record

ReviewTransplantation2010

MicroRNAs: small RNAs with big effects.

Dany Anglicheau, Thangamani Muthukumar, Manikkam Suthanthiran

Abstract readReview
In one paragraph

Review in Transplantation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Review
  6. Population-Specific Exploration ofInternational journal of molecular sciences · 2026
    Article
  7. Article
  8. Article
  9. Aging and sinus node dysfunction: mechanisms and future directions.Clinical science (London, England : 1979) · 2025
    Review
  10. MicroRNAs' Impact on Heart Diseases.International journal of molecular sciences · 2025
    Review
  11. Article
  12. Review
  13. Mechanisms of apoptosis-related non-coding RNAs in ovarian cancer: a narrative review.Apoptosis : an international journal on programmed cell death · 2025
    Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Review

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Dany AnglicheauDivision of Nephrology, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Thangamani Muthukumar
Manikkam Suthanthiran

Funding

Biomolecular Markers for Safe Minimization of ImmunosuppressionR37AI051652 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI SUTHANTHIRAN, MANIKKAM · 2009 to 2021
$4.7M
FoxP3 Regulatory Network mRNA Profiles and Human Renal Transplant OutcomesR01AI072790 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI SUTHANTHIRAN, MANIKKAM · 2007 to 2011
$3.3M
NIAID NIH HHS R01 AI072790NIAID NIH HHS R01AI72790NIAID NIH HHS R37 AI051652NIAID NIH HHS R37AI 51652
6 · The paper itself

Abstract

MicroRNAs (miRNAs) are evolutionarily conserved, small ( approximately 20-25 nucleotides), single-stranded molecules that suppress the expression of protein-coding genes by translational repression, messenger RNA degradation, or both. More than 700 miRNAs have been identified in the human genome. Amazingly, a single miRNA can regulate the expression of hundreds of mRNAs or proteins within a cell. The small RNAs are fast emerging as master regulators of innate and adaptive immunity and likely to play a pivotal role in transplantation. The clinical application of RNA sequencing ("next-generation sequencing") should facilitate transcriptome profiling at an unprecedented resolution. We provide an overview of miRNA biology and their hypothesized roles in transplantation.

Indexed as

AnimalsBase SequenceB-LymphocytesCaenorhabditis elegansConserved SequenceEvolution, MolecularGenome, HumanHumansImmunity, InnateMicroRNAsPolymerase Chain ReactionRNA, MessengerT-LymphocytesT-Lymphocytes, Helper-InducerT-Lymphocytes, Regulatorylin-4 microRNA, C elegansMicroRNAsRNA, Messenger

Identifiers

PMID20574417
PMCPMC3094098

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.