ArticleInvestigative ophthalmology & visual science2010
Increased hyaluronan synthase-2 mRNA expression and hyaluronan accumulation with choroidal thickening: response during recovery from induced myopia.
Article in Investigative ophthalmology & visual science, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Critical role of lipid metabolism in axial myopia development.International journal of ophthalmology · 2025Review
- Axial Shortening in Myopic Children after Repeated Low-Level Red-Light Therapy: Post Hoc Analysis of a Randomized Trial.Ophthalmology and therapy · 2023Article
- Functional integration of eye tissues and refractive eye development: Mechanisms and pathways.Experimental eye research · 2021Review
- Retinoic acid synthesis by a population of choroidal stromal cells.Experimental eye research · 2020Article
- Multi-Scale Modeling of Vision-Guided Remodeling and Age-Dependent Growth of the Tree Shrew Sclera During Eye Development and Lens-Induced Myopia.Journal Of Elasticity · 2017Article
- The effect of topical administration of cyclopentolate on ocular biometry: An analysis for mouse and human models.Scientific reports · 2017Article
- Effect of MT3 on Retinal and Choroidal TGF-Journal of ophthalmology · 2017Article
- Bidirectional Expression of Metabolic, Structural, and Immune Pathways in Early Myopia and Hyperopia.Frontiers in neuroscience · 2016Article
- Gene expression signatures in tree shrew choroid during lens-induced myopia and recovery.Experimental eye research · 2014Article
- Gene expression signatures in tree shrew sclera in response to three myopiagenic conditions.Investigative ophthalmology & visual science · 2013Article
- The choroid as a sclera growth regulator.Experimental eye research · 2013Review
- Identification of RALDH2 as a visually regulated retinoic acid synthesizing enzyme in the chick choroid.Investigative ophthalmology & visual science · 2012Article
- Regulation of the biphasic decline in scleral proteoglycan synthesis during the recovery from induced myopia.Experimental eye research · 2011Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeSeveral studies have convincingly shown that in chicks, compensation for imposed focus involves immediate changes in choroid thickness. The molecular events associated with choroidal thickening and the regulation of the choroidal response are largely unknown.
methodsForm-deprivation myopia was induced in the right eyes of 2-day-old chicks by the application of translucent occluders for 10 days and was followed by unrestricted vision for an additional 1 to 20 days (recovery). Individual choroids were isolated from treated and control eyes and used for reverse transcription-quantitative PCR, hyaluronan (HA) localization with biotinylated hyaluronic acid binding protein (b-HABP), and analyses of HA size and concentration by size exclusion chromatography-multiangle laser light scattering (SEC-MALLS).
resultsHAS2 gene expression increased significantly after 6 hours of unrestricted vision (>7-fold) and peaked at 24 hours (>9-fold). In untreated eyes, HA was localized to perivascular sheaths of larger choroidal blood vessels; however, after 4 to 15 days of recovery, intense labeling for HA was detected throughout the thickened choroidal stroma. Analyses of choroidal HA by SEC-MALLS indicated that HA concentration was significantly increased in recovering choroids compared with controls after 4 to 8 days of recovery (≈3.5-fold).
conclusionsNewly synthesized HA accumulates in the choroidal stroma of recovering eyes and is most likely responsible for the stromal swelling observed during recovery from myopia. This HA accumulation is initiated by a rapid increase in choroidal expression of the HAS2 gene in response to myopic defocus.
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