ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2010
Sex differences in acute ANG II-mediated hemodynamic responses in mice.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Endothelial Piezo1 Hyperactivity Drives Neurovascular Dysfunction in Hypertension.Circulation research · 2026Article
- The renal vasodilatation from β-adrenergic activation in vivo in rats is not driven by KExperimental physiology · 2024Article
- Sex and strain differences in renal hemodynamics in mice.Physiological reports · 2023Article
- Age- and Gender-Related Differences in Renal Vascular Responses to Angiotensin II in Rats: The Role of the Mas Receptor.Journal of aging research · 2023Article
- Angiotensin II-induced endothelial dysfunction: Impact of sex, genetic background, and rho kinase.Physiological reports · 2022Article
- Hydroxyurea improves nitric oxide bioavailability in humanized sickle cell mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Lack of Connexins 40 and 45 Reduces Local and Conducted Vasoconstrictor Responses in the Murine Afferent Arterioles.Frontiers in physiology · 2020Article
- Sex differences in endothelial function important to vascular health and overall cardiovascular disease risk across the lifespan.American journal of physiology. Heart and circulatory physiology · 2018Review
- Superoxide Dismutase Activity in Small Mesenteric Arteries Is Downregulated by Angiotensin II but Not by Hypertension.Toxicological research · 2018Article
- Early life stress induces immune priming in kidneys of adult male rats.American journal of physiology. Renal physiology · 2018Article
- The Role of Angiotensin II Infusion on the Baroreflex Sensitivity and Renal Function in Intact and Bilateral Renal Denervation Rats.Advanced biomedical research · 2018Article
- Genetic Interference With Endothelial PPAR-γ (Peroxisome Proliferator-Activated Receptor-γ) Augments Effects of Angiotensin II While Impairing Responses to Angiotensin 1-7.Hypertension (Dallas, Tex. : 1979) · 2017Article
- Cross-sex transplantation alters gene expression and enhances inflammatory response in the transplanted kidneys.American journal of physiology. Renal physiology · 2017Article
- Endothelin-1 contributes to the progression of renal injury in sickle cell disease via reactive oxygen species.British journal of pharmacology · 2016Article
- Early life stress sensitizes the renal and systemic sympathetic system in rats.American journal of physiology. Renal physiology · 2013Article
- Sex differences in the enhanced responsiveness to acute angiotensin II in growth-restricted rats: role of fasudil, a Rho kinase inhibitor.American journal of physiology. Renal physiology · 2013Article
- The "his and hers" of the renin-angiotensin system.Current hypertension reports · 2013Review
- Direct evidence for intrarenal chymase-dependent angiotensin II formation on the diabetic renal microvasculature.Hypertension (Dallas, Tex. : 1979) · 2013Article
- Hypersensitivity to acute ANG II in female growth-restricted offspring is exacerbated by ovariectomy.American journal of physiology. Regulatory, integrative and comparative physiology · 2011Article
- Prenatal water deprivation alters brain angiotensin system and dipsogenic changes in the offspring.Brain research · 2011Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Male sex is associated with higher blood pressure and greater renal injury, perhaps related to greater sensitivity to ANG II. In anesthetized male and female C57BLK/6 mice, we assessed responses of mean arterial pressure (MAP) and renal vascular resistance (RVR; Transonic flow probe) to acute bolus injections of ANG II (0.3-3.0 microg/kg iv) and phenylephrine (PE; 30-300 microg/kg) during low-, normal-, and high-sodium diets. The role of reactive oxygen species was determined by coadministration of tempol. ANG II type 1 and type 2 (AT1 and AT2) receptor and endothelial nitric oxide synthase (NOS3) expression were determined in dissected kidney vessels. While no difference was found on the low-sodium (LS) diet, MAP and RVR responses to ANG II were greater in males during the normal-sodium (NS) and high-sodium (HS) diets (e.g., RVR response at ANG II 3.0 microg/kg during NS: +329 +/- 22 vs. +271 +/- 28 mmHg.ml(-1).min, P = 0.029, effect size = 0.75). Tempol had no effect on the sex-dependent responses on any of the diets. On the LS diet, AT1 and AT2 receptor expression was higher in males. No sex differences were found on the NS diet. On the HS diet, AT1 was higher, and NOS3 expression was lower in males. Acute responses to ANG II are greater in male mice during NS and HS diets, which is, in part, related to differences in AT1, AT2, and NOS3 expression in kidney vessels. Mouse models will be useful to study the role of sex differences in ANG II sensitivity for cardiovascular and renal disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.